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Synthesis, biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and vascular diseases
H Sheng, H Sun - Natural product reports, 2011 - pubs.rsc.org
Covering: up to May 2010 This review (with 335 references cited) is devoted to pentacyclic
triterpenes. The total synthesis, semi-synthesis, structural modification, and metabolic …
triterpenes. The total synthesis, semi-synthesis, structural modification, and metabolic …
The pentacyclic triterpenoids in herbal medicines and their pharmacological activities in diabetes and diabetic complications
Pentacyclic triterpenoids including the oleanane, ursane and lupane groups are widely
distributed in many medicinal plants, such as Glycyrrhiza species, Gymnema species …
distributed in many medicinal plants, such as Glycyrrhiza species, Gymnema species …
Oleanolic, ursolic, and betulinic acids as food supplements or pharmaceutical agents for type 2 diabetes: promise or illusion?
Oleanolic (OA), ursolic (UA), and betulinic (BA) acids are three triterpenic acids (TAs) with
potential effects for treatment of type 2 diabetes (T2DM). Mechanistic studies showed that …
potential effects for treatment of type 2 diabetes (T2DM). Mechanistic studies showed that …
Oleanolic acid improves hepatic insulin resistance via antioxidant, hypolipidemic and anti-inflammatory effects
X Wang, R Liu, W Zhang, X Zhang, N Liao… - Molecular and Cellular …, 2013 - Elsevier
Insulin resistance is the hallmark of type 2 diabetes mellitus (T2DM), which is closely related
to disorder of lipid metabolism. The study was designed to evaluate the effects of oleanolic …
to disorder of lipid metabolism. The study was designed to evaluate the effects of oleanolic …
Ethnopharmacological, Phytochemical, Pharmacological, and Toxicological Review on Senna auriculata (L.) Roxb.: A Special Insight to Antidiabetic Property
Avartaki (Senna auriculata (L.) Roxb. syn. Cassia auriculata L.; Family-Fabaceae) is a
traditional medicinal plant, widely used for the treatment of various ailments in Ayurveda and …
traditional medicinal plant, widely used for the treatment of various ailments in Ayurveda and …
[HTML][HTML] Antidiabetic potential of commonly available fruit plants in Bangladesh: updates on prospective phytochemicals and their reported MoAs
Diabetes mellitus is a life-threatening disorder affecting people of all ages and adversely
disrupts their daily functions. Despite the availability of numerous synthetic-antidiabetic …
disrupts their daily functions. Despite the availability of numerous synthetic-antidiabetic …
Anti-diabetic agents from natural products—an update from 2004 to 2009
LW Qi, EH Liu, C Chu, YB Peng… - Current Topics in …, 2010 - ingentaconnect.com
Diabetes mellitus (DM), the third killer of the mankind health along with cancer,
cardiovascular and cerebrovascular diseases, is one of the most challenging diseases …
cardiovascular and cerebrovascular diseases, is one of the most challenging diseases …
[HTML][HTML] Pentacyclic triterpene oleanolic acid protects against cardiac aging through regulation of mitophagy and mitochondrial integrity
Y Gong, Y Luo, S Liu, J Ma, F Liu, Y Fang, F Cao… - … Et Biophysica Acta (BBA …, 2022 - Elsevier
Advanced aging exhibits altered cardiac geometry and function involving mitochondrial
anomaly. Natural compounds display promises in the regulation of cardiac homeostasis via …
anomaly. Natural compounds display promises in the regulation of cardiac homeostasis via …
[HTML][HTML] Hypoglycemic natural products with in vivo activities and their mechanisms: a review
W Ma, L **ao, H Liu, X Hao - Food Science and Human Wellness, 2022 - Elsevier
Diabetes mellitus (DM) is a metabolic disorder disease, and the number of diabetic patients
will reach 578 million by 2030 predictably. Currently, 8 classes of small molecular drugs are …
will reach 578 million by 2030 predictably. Currently, 8 classes of small molecular drugs are …
The effect and mechanism of oleanolic acid in the treatment of metabolic syndrome and related cardiovascular diseases
Q Luo, Y Wei, X Lv, W Chen, D Yang, Q Tuo - Molecules, 2024 - mdpi.com
Metabolic syndromes (MetS) and related cardiovascular diseases (CVDs) pose a serious
threat to human health. MetS are metabolic disorders characterized by obesity, dyslipidemia …
threat to human health. MetS are metabolic disorders characterized by obesity, dyslipidemia …