GPCR desensitization: Acute and prolonged phases
S Rajagopal, SK Shenoy - Cellular signalling, 2018 - Elsevier
G protein-coupled receptors (GPCRs) transduce a wide array of extracellular signals and
regulate virtually every aspect of physiology. While GPCR signaling is essential …
regulate virtually every aspect of physiology. While GPCR signaling is essential …
Structural insights into microtubule function
E Nogales - Annual review of biophysics and biomolecular …, 2001 - annualreviews.org
▪ Abstract Microtubules are polymers that are essential for, among other functions, cell
transport and cell division in all eukaryotes. The regulation of the microtubule system …
transport and cell division in all eukaryotes. The regulation of the microtubule system …
Preferential transformation of human neuronal cells by human adenoviruses and the origin of HEK 293 cells
G Shaw, S Morse, M Ararat, FL Graham - The FASEB journal, 2002 - Wiley Online Library
The 293 cell line was derived by transformation of primary cultures of human embryonic
kidney (HEK) cells with sheared adenovirus (Ad) 5 DNA. A combination of immunostaining …
kidney (HEK) cells with sheared adenovirus (Ad) 5 DNA. A combination of immunostaining …
G protein-coupled receptor kinases: more than just kinases and not only for GPCRs
EV Gurevich, JJG Tesmer, A Mushegian… - Pharmacology & …, 2012 - Elsevier
G protein-coupled receptor (GPCR) kinases (GRKs) are best known for their role in
homologous desensitization of GPCRs. GRKs phosphorylate activated receptors and …
homologous desensitization of GPCRs. GRKs phosphorylate activated receptors and …
Desensitization of G protein–coupled receptors and neuronal functions
▪ Abstract G protein–coupled receptors (GPCRs) have proven to be the most highly
favorable class of drug targets in modern pharmacology. Over 90% of nonsensory GPCRs …
favorable class of drug targets in modern pharmacology. Over 90% of nonsensory GPCRs …
G protein-coupled receptors: III. New roles for receptor kinases and β-arrestins in receptor signaling and desensitization
RJ Lefkowitz - Journal of Biological Chemistry, 1998 - ASBMB
Of the many forms of GPCR1 regulation none has received as much attention as the process
of receptor desensitization, ie the waning responsiveness of the receptors in the face of …
of receptor desensitization, ie the waning responsiveness of the receptors in the face of …
G protein-coupled receptor kinases as therapeutic targets in the heart
G protein-coupled receptors (GPCRs) are critical cellular sensors that mediate numerous
physiological processes. In the heart, multiple GPCRs are expressed on various cell types …
physiological processes. In the heart, multiple GPCRs are expressed on various cell types …
β-arrestin-biased allosteric modulator of NTSR1 selectively attenuates addictive behaviors
Small molecule neurotensin receptor 1 (NTSR1) agonists have been pursued for more than
40 years as potential therapeutics for psychiatric disorders, including drug addiction. Clinical …
40 years as potential therapeutics for psychiatric disorders, including drug addiction. Clinical …
RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice
KY Miyashiro, A Beckel-Mitchener, TP Purk, KG Becker… - Neuron, 2003 - cell.com
The Fragile X mental retardation-1 (Fmr1) gene encodes a multifunctional protein, FMRP,
with intrinsic RNA binding activity. We have developed an approach, antibody-positioned …
with intrinsic RNA binding activity. We have developed an approach, antibody-positioned …
Synucleins are a novel class of substrates for G protein-coupled receptor kinases
G protein-coupled receptor kinases (GRKs) specifically recognize and phosphorylate the
agonist-occupied form of numerous G protein-coupled receptors (GPCRs), ultimately …
agonist-occupied form of numerous G protein-coupled receptors (GPCRs), ultimately …