Drug release from in situ forming implants and advances in release testing

X Wang, DJ Burgess - Advanced Drug Delivery Reviews, 2021 - Elsevier
In situ forming implants, defined as liquid formulations that generate solid or semisolid
depots following administration, have shown a range of advantages in drug delivery. This …

Patient-centric long-acting injectable and implantable Platforms─ An industrial perspective

S Alidori, R Subramanian, R Holm - Molecular pharmaceutics, 2024 - ACS Publications
The increasing focus on patient centricity in the pharmaceutical industry over the past
decade and the changing healthcare landscape, driven by factors such as increased access …

Preparation of shell-core fiber-encapsulated Lactobacillus rhamnosus 1.0320 using coaxial electrospinning

C Xu, J Ma, Z Liu, W Wang, X Liu, S Qian, L Chen, L Gu… - Food Chemistry, 2023 - Elsevier
In this study, shell-core fibers were successfully prepared by using Eudragit S100 (ES100)
and poly (vinyl alcohol)(PVA)/pectin (PEC) through coaxial electrospinning technology. The …

Current trends in PLGA based long-acting injectable products: The industry perspective

OS Muddineti, A Omri - Expert Opinion on Drug Delivery, 2022 - Taylor & Francis
Introduction Poly (lactic-co-glycolic acid)(PLGA) has been used in many long-acting drug
formulations, which have been approved by the US Food and Drug Administration (FDA) …

Burst release from in situ forming PLGA-based implants: 12 effectors and ways of correction

EOО Bakhrushina, PSS Sakharova, PDD Konogorova… - Pharmaceutics, 2024 - mdpi.com
In modern pharmaceutical technology, modified-release dosage forms, such as in situ
formed implants, are gaining rapidly in popularity. These dosage forms are created based …

An overview of PLGA in-situ forming implants based on solvent exchange technique: effect of formulation components and characterization

TM Ibrahim, NA El-Megrab… - Pharmaceutical …, 2021 - Taylor & Francis
As a result of the low oral bioavailability of several drugs, there is a renewed interest for
parenteral administration to target their absorption directly into the blood bypassing the long …

Fabrication and optimization of itraconazole-loaded zein-based nanoparticles in coated capsules as a promising colon-targeting approach pursuing opportunistic …

S Adel, RH Fahmy, I Elsayed, MI Mohamed… - Drug Delivery and …, 2023 - Springer
Abstract Itraconazole (ITZ), a broad-spectrum antifungal drug, was formulated into colon-
targeting system aiming to treat opportunistic colonic fungal infections that commonly infect …

One-pot self-assembly of core-shell nanoparticles within fibers by coaxial electrospinning for intestine-targeted delivery of curcumin

L Hou, L Zhang, C Yu, J Chen, X Ye, F Zhang… - Foods, 2023 - mdpi.com
Nanotechniques for curcumin (Cur) encapsulation provided a potential capability to avoid
limitations and improve biological activities in food and pharmaceutics. Different from multi …

Metronidazole-Loaded Camphor-Based In Situ Forming Matrix for Periodontitis Treatment

K Jitrangsri, N Lertsuphotvanit, N Kabthong… - AAPS …, 2023 - Springer
Periodontitis is a widespread oral health problem caused by bacterial infections that lead to
tooth loss and other systemic diseases. The aim of this study was to provide an alternative …

Moxifloxacin HCl -loaded Cellulose Acetate Butylate In Situ Forming Gel for Periodontitis Treatment

W Thammasut, C Rojviriya, P Chaiya… - AAPS …, 2024 - Springer
Periodontitis presents significant treatment challenges due to its complexity and potential
complications. In response, an in situ forming gel (ISG) loaded with moxifloxacin HCl (Mx) …