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The many ways of Wnt in cancer
P Polakis - Current opinion in genetics & development, 2007 - Elsevier
More than 20 years ago, the oncogenicity of a Wnt ligand was revealed in a series of
experiments originating with random proviral integration in mice. The significance of Wnt …
experiments originating with random proviral integration in mice. The significance of Wnt …
Protein phosphatase 2A regulatory subunits and cancer
The serine/threonine protein phosphatase (PP2A) is a trimeric holoenzyme that plays an
integral role in the regulation of a number of major signaling pathways whose deregulation …
integral role in the regulation of a number of major signaling pathways whose deregulation …
[HTML][HTML] Selective PP2A enhancement through biased heterotrimer stabilization
Impairment of protein phosphatases, including the family of serine/threonine phosphatases
designated PP2A, is essential for the pathogenesis of many diseases, including cancer. The …
designated PP2A, is essential for the pathogenesis of many diseases, including cancer. The …
[HTML][HTML] CIP2A inhibits PP2A in human malignancies
Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for
the transformation of human cells. However, the molecular mechanisms by which PP2A …
the transformation of human cells. However, the molecular mechanisms by which PP2A …
Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A
The protein phosphatase 2A (PP2A) heterotrimer PP2A-B56α is a human tumour
suppressor. However, the molecular mechanisms inhibiting PP2A-B56α in cancer are poorly …
suppressor. However, the molecular mechanisms inhibiting PP2A-B56α in cancer are poorly …
Human Merkel cell polyomavirus small T antigen is an oncoprotein targeting the 4E-BP1 translation regulator
Merkel cell polyomavirus (MCV) is the recently discovered cause of most Merkel cell
carcinomas (MCCs), an aggressive form of nonmelanoma skin cancer. Although MCV is …
carcinomas (MCCs), an aggressive form of nonmelanoma skin cancer. Although MCV is …
Structure of the protein phosphatase 2A holoenzyme
Summary Protein Phosphatase 2A (PP2A) plays an essential role in many aspects of
cellular physiology. The PP2A holoenzyme consists of a heterodimeric core enzyme, which …
cellular physiology. The PP2A holoenzyme consists of a heterodimeric core enzyme, which …
Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme
Abstract Protein phosphatase 2A (PP2A) is a principal Ser/Thr phosphatase, the
deregulation of which is associated with multiple human cancers, Alzheimer's disease and …
deregulation of which is associated with multiple human cancers, Alzheimer's disease and …
Species-and cell type-specific requirements for cellular transformation
Recent evidence suggests that human cells require more genetic changes for neoplastic
transformation than do their murine counterparts. However, a precise enumeration of these …
transformation than do their murine counterparts. However, a precise enumeration of these …
Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55α regulatory subunit targeting of the protein phosphatase 2A holoenzyme to …
YC Kuo, KY Huang, CH Yang, YS Yang, WY Lee… - Journal of Biological …, 2008 - jbc.org
Akt is a protein serine/threonine kinase that is involved in the regulation of diverse cellular
processes. Phosphorylation of Akt at regulatory residues Thr-308 and Ser-473 leads to its …
processes. Phosphorylation of Akt at regulatory residues Thr-308 and Ser-473 leads to its …