Diagnosis and treatment of heterozygous familial hypercholesterolemia

MP McGowan, SH Hosseini Dehkordi… - Journal of the …, 2019 - Am Heart Assoc
Familial hypercholesterolemia (FH) is a common yet underdiagnosed autosomal dominant
disorder that affects% 1 in 220 individuals globally. 1 FH is characterized by lifelong …

The evolving future of PCSK9 inhibitors

RS Rosenson, RA Hegele, S Fazio… - Journal of the American …, 2018 - jacc.org
Variants in proprotein convertase subtilisin/kexin type 9 (PCSK9) provide insights into
mechanisms regulating low-density lipoprotein (LDL) levels. Human monoclonal antibodies …

Guidelines on the use of therapeutic apheresis in clinical practice–evidence‐based approach from the Writing Committee of the American Society for Apheresis: the …

A Padmanabhan, L Connelly‐Smith… - Journal of clinical …, 2019 - Wiley Online Library
ABSTRACT The American Society for Apheresis (ASFA) Journal of Clinical Apheresis (JCA)
Special Issue Writing Committee is charged with reviewing, updating and categorizing …

Guidelines on the Use of therapeutic apheresis in clinical practice–Evidence‐Based approach from the Writing Committee of the American Society for Apheresis: The …

L Connelly‐Smith, CR Alquist, NA Aqui… - Journal of clinical …, 2023 - Wiley Online Library
Abstract The American Society for Apheresis (ASFA) Journal of Clinical Apheresis (JCA)
Special Issue Writing Committee is charged with reviewing, updating, and categorizing …

[HTML][HTML] PoLA/CFPiP/PCS/PSLD/PSD/PSH guidelines on diagnosis and therapy of lipid disorders in Poland 2021

M Banach, P Burchardt, K Chlebus… - Archives of Medical …, 2021 - ncbi.nlm.nih.gov
Moreover, over the last few years the approach to treatment of patients with a high
cardiovascular risk has totally changed from treatment aimed at a specific risk factor (ie …

Practical guidance for combination lipid-modifying therapy in high-and very-high-risk patients: a statement from a European Atherosclerosis Society Task Force

M Averna, M Banach, E Bruckert, H Drexel, M Farnier… - Atherosclerosis, 2021 - Elsevier
Abstract Background and aims This European Atherosclerosis Society (EAS) Task Force
provides practical guidance for combination therapy for elevated low-density lipoprotein …

Long-term evolocumab in patients with familial hypercholesterolemia

RD Santos, EA Stein, GK Hovingh, DJ Blom… - Journal of the American …, 2020 - jacc.org
Background Proprotein convertase subtilisin/kexin type 9 inhibitor therapy is a treatment
option for patients with familial hypercholesterolemia (FH) who are unable to reach low …

Guidelines for the diagnosis and treatment of pediatric familial hypercholesterolemia 2022

M Harada-Shiba, A Ohtake, D Sugiyama… - … of atherosclerosis and …, 2023 - jstage.jst.go.jp
As atherosclerosis begins in childhood, early diagnosis and treatment of familial
hypercholesterolemia (FH) is considered necessary. The basic diagnosis of pediatric FH …

Efficacy and safety of alirocumab in adults with homozygous familial hypercholesterolemia: the ODYSSEY HoFH trial

DJ Blom, M Harada-Shiba, P Rubba, D Gaudet… - Journal of the American …, 2020 - jacc.org
Abstract Background Homozygous familial hypercholesterolemia (HoFH) is characterized by
extremely elevated low-density lipoprotein–cholesterol (LDL-C) levels and early onset …

2017 Update of ESC/EAS Task Force on practical clinical guidance for proprotein convertase subtilisin/kexin type 9 inhibition in patients with atherosclerotic …

U Landmesser, MJ Chapman, JK Stock… - European heart …, 2018 - academic.oup.com
The first randomized controlled data from cardiovascular outcomes trials with proprotein
convertase subtilisin/kexin type 9 (PCSK9) inhibitors have now been reported. 1, 2 This …