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Cancer cell heterogeneity and plasticity: A paradigm shift in glioblastoma
Phenotypic plasticity has emerged as a major contributor to intra-tumoral heterogeneity and
treatment resistance in cancer. Increasing evidence shows that glioblastoma (GBM) cells …
treatment resistance in cancer. Increasing evidence shows that glioblastoma (GBM) cells …
Mechanisms of regeneration and fibrosis in the endometrium
The uterine lining (endometrium) regenerates repeatedly over the life span as part of its
normal physiology. Substantial portions of the endometrium are shed during childbirth …
normal physiology. Substantial portions of the endometrium are shed during childbirth …
Engineered matrices reveal stiffness-mediated chemoresistance in patient-derived pancreatic cancer organoids
Pancreatic ductal adenocarcinoma (PDAC) is characterized by its fibrotic and stiff
extracellular matrix. However, how the altered cell/extracellular-matrix signalling contributes …
extracellular matrix. However, how the altered cell/extracellular-matrix signalling contributes …
Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B
Cancer stem cells (CSCs) are a subpopulation of cancer cells endowed with high
tumorigenic, chemoresistant and metastatic potential. Nongenetic mechanisms of acquired …
tumorigenic, chemoresistant and metastatic potential. Nongenetic mechanisms of acquired …
Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment
The identity and unique capacity of cancer stem cells (CSC) to drive tumor growth and
resistance have been challenged in brain tumors. Here we report that cells expressing CSC …
resistance have been challenged in brain tumors. Here we report that cells expressing CSC …
Mechanisms of new blood-vessel formation and proliferative heterogeneity of endothelial cells
H Naito, T Iba, N Takakura - International immunology, 2020 - academic.oup.com
The vast blood-vessel network of the circulatory system is crucial for maintaining bodily
homeostasis, delivering essential molecules and blood cells, and removing waste products …
homeostasis, delivering essential molecules and blood cells, and removing waste products …
Cancer stem cell quiescence and plasticity as major challenges in cancer therapy
W Chen, J Dong, J Haiech, MC Kilhoffer… - Stem cells …, 2016 - Wiley Online Library
Cells with stem‐like properties, tumorigenic potential, and treatment‐resistant phenotypes
have been identified in many human malignancies. Based on the properties they share with …
have been identified in many human malignancies. Based on the properties they share with …