Cancer cell heterogeneity and plasticity: A paradigm shift in glioblastoma

YA Yabo, SP Niclou, A Golebiewska - Neuro-oncology, 2022 - academic.oup.com
Phenotypic plasticity has emerged as a major contributor to intra-tumoral heterogeneity and
treatment resistance in cancer. Increasing evidence shows that glioblastoma (GBM) cells …

Mechanisms of regeneration and fibrosis in the endometrium

CJ Ang, TD Skokan, KL McKinley - Annual review of cell and …, 2023 - annualreviews.org
The uterine lining (endometrium) regenerates repeatedly over the life span as part of its
normal physiology. Substantial portions of the endometrium are shed during childbirth …

Engineered matrices reveal stiffness-mediated chemoresistance in patient-derived pancreatic cancer organoids

BL LeSavage, D Zhang, C Huerta-López, AE Gilchrist… - Nature Materials, 2024 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is characterized by its fibrotic and stiff
extracellular matrix. However, how the altered cell/extracellular-matrix signalling contributes …

Type I IFNs promote cancer cell stemness by triggering the epigenetic regulator KDM1B

M Musella, A Guarracino, N Manduca, C Galassi… - Nature …, 2022 - nature.com
Cancer stem cells (CSCs) are a subpopulation of cancer cells endowed with high
tumorigenic, chemoresistant and metastatic potential. Nongenetic mechanisms of acquired …

Stem cell-associated heterogeneity in Glioblastoma results from intrinsic tumor plasticity shaped by the microenvironment

A Dirkse, A Golebiewska, T Buder, PV Nazarov… - Nature …, 2019 - nature.com
The identity and unique capacity of cancer stem cells (CSC) to drive tumor growth and
resistance have been challenged in brain tumors. Here we report that cells expressing CSC …

Mechanisms of new blood-vessel formation and proliferative heterogeneity of endothelial cells

H Naito, T Iba, N Takakura - International immunology, 2020 - academic.oup.com
The vast blood-vessel network of the circulatory system is crucial for maintaining bodily
homeostasis, delivering essential molecules and blood cells, and removing waste products …

Cancer stem cell quiescence and plasticity as major challenges in cancer therapy

W Chen, J Dong, J Haiech, MC Kilhoffer… - Stem cells …, 2016 - Wiley Online Library
Cells with stem‐like properties, tumorigenic potential, and treatment‐resistant phenotypes
have been identified in many human malignancies. Based on the properties they share with …