[HTML][HTML] Spatiotemporal transcriptome analysis reveals critical roles for mechano-sensing genes at the border zone in remodeling after myocardial infarction
S Yamada, T Ko, S Hatsuse, S Nomura… - Nature Cardiovascular …, 2022 - nature.com
The underlying mechanisms of ventricular remodeling after myocardial infarction (MI) remain
largely unknown. In this study, we performed an integrative analysis of spatial …
largely unknown. In this study, we performed an integrative analysis of spatial …
The arginase pathway in neonatal brain hypoxia-ischemia
Brain damage after hypoxia-ischemia (HI) occurs in an age-dependent manner.
Neuroprotective strategies assumed to be effective in adults might have deleterious effects …
Neuroprotective strategies assumed to be effective in adults might have deleterious effects …
Klf4 deficiency exacerbates myocardial ischemia/reperfusion injury in mice via enhancing ROCK1/DRP1 pathway-dependent mitochondrial fission
Y Li, Z **ong, Y Jiang, H Zhou, L Yi, Y Hu, X Zhai… - Journal of Molecular and …, 2023 - Elsevier
Rational Excessive mitochondrial fission is considered key process involved in myocardial
ischemia/reperfusion (I/R) injury. However, the upstream mechanism remains largely …
ischemia/reperfusion (I/R) injury. However, the upstream mechanism remains largely …
Ribonucleicacid interference or small molecule inhibition of Runx1 in the border zone prevents cardiac contractile dysfunction following myocardial infarction
TP Martin, EA MacDonald, A Bradley… - Cardiovascular …, 2023 - academic.oup.com
Aims Myocardial infarction (MI) is a major cause of death worldwide. Effective treatments are
required to improve recovery of cardiac function following MI, with the aim of improving …
required to improve recovery of cardiac function following MI, with the aim of improving …
Recombinant human collagen hydrogel rapidly reduces methylglyoxal adducts within cardiomyocytes and improves borderzone contractility after myocardial infarction …
S McLaughlin, V Sedlakova, Q Zhang… - Advanced Functional …, 2022 - Wiley Online Library
Methylglyoxal (MG) production after myocardial infarction (MI) leads to advanced glycation
end‐product formation, adverse remodeling, and loss of cardiac function. The extracellular …
end‐product formation, adverse remodeling, and loss of cardiac function. The extracellular …
A novel 3D imaging approach for quantification of GLUT4 levels across the intact myocardium
A Geiser, S Currie, H Al-Hasani, A Chadt… - Journal of Cell …, 2024 - journals.biologists.com
Cellular heterogeneity is a well-accepted feature of tissues, and both transcriptional and
metabolic diversity have been revealed by numerous approaches, including optical imaging …
metabolic diversity have been revealed by numerous approaches, including optical imaging …
[HTML][HTML] PACAP neuropeptide promotes Hepatocellular Protection via CREB-KLF4 dependent autophagy in mouse liver Ischemia Reperfusion Injury
Z Xue, Y Zhang, Y Liu, C Zhang, F Gao, RW Busuttil… - Theranostics, 2020 - ncbi.nlm.nih.gov
Organ ischemia reperfusion injury (IRI), associated with acute hepatocyte death, remains an
unresolved problem in clinical orthotopic liver transplantation (OLT). Autophagy, an …
unresolved problem in clinical orthotopic liver transplantation (OLT). Autophagy, an …
Biofabrication of advanced in vitro 3D models to study ischaemic and doxorubicin-induced myocardial damage
Current preclinical in vitro and in vivo models of cardiac injury typical of myocardial infarction
(MI, or heart attack) and drug induced cardiotoxicity mimic only a few aspects of these …
(MI, or heart attack) and drug induced cardiotoxicity mimic only a few aspects of these …
[HTML][HTML] NKX2-5 regulates vessel remodeling in scleroderma-associated pulmonary arterial hypertension
I Papaioannou, A Dritsoula, P Kang, RS Baliga… - JCI insight, 2024 - ncbi.nlm.nih.gov
NKX2-5 is a member of the homeobox-containing transcription factors critical in regulating
tissue differentiation in development. Here, we report a role for NKX2-5 in vascular smooth …
tissue differentiation in development. Here, we report a role for NKX2-5 in vascular smooth …
Identification of malonylation, succinylation, and glutarylation in serum proteins of acute myocardial infarction patients
Purpose To identify protein malonylation, succinylation, and glutarylation in human and rat
serum. Experimental design Immunoprecipitation coupled with MS/MS is employed to …
serum. Experimental design Immunoprecipitation coupled with MS/MS is employed to …