Antibacterial, membrane-lytic peptides belong to the innate immune system and host
defense mechanism of a multitude of animals and plants. The largest group of peptide …

Amphibian skin is directly exposed to different environments. Amphibians interact with
environmental factors including microorganisms, parasites, predators, and physical factors …

The emergence of new pathogens and multidrug resistant bacteria is an important public
health issue that requires the development of novel classes of antibiotics. Antimicrobial …

Granular glands in the skins of frogs of the genus Rana, a widely distributed group with over
250 species, synthesize and secrete a remarkably diverse array of peptides with …

Species right across the evolutionary scale from insects to mammals use peptides as part of
their host-defense system to counter microbial infection. The primary structures of a large …

Insects are amazingly resistant to bacterial infections. To combat pathogens, insects rely on
cellular and humoral mechanisms, innate immunity being dominant in the latter category …

Antimicrobial peptides (AMPs) possess great potential for combating drug-resistant bacteria.
Thanatin is a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP which was …

Covering: up to the end of 2005 This review covers the literature on the subject of
biologically active peptides from the glands of amphibians. These include neuropeptides …

Brevinin‐2R is a novel non‐hemolytic defensin that was isolated from the skin of the frog
Rana ridibunda. It exhibits preferential cytotoxicity towards malignant cells, including Jurkat …

The high-resolution three-dimensional structure of an antimicrobial peptide has implications
for the mechanism of its antimicrobial activity, as the conformation of the peptide provides …