ABSTRACT Carbon/nitrogen (C/N) balance sensing is a key requirement for the
maintenance of cellular homeostasis. Therefore, cyanobacteria have evolved a …

The metabolite 2-oxoglutarate (also known as α-ketoglutarate, 2-ketoglutaric acid, or
oxoglutaric acid) lies at the intersection between the carbon and nitrogen metabolic …

The PII proteins are one of the most widely distributed families of signal transduction
proteins in nature. They are pivotal players in the control of nitrogen metabolism in bacteria …

Cyanobacteria evolved sophisticated mechanisms allowing them to cope with
environmental depletion of combined nitrogen. Here, we describe progress in …

Glutamine synthetases (GS) play central roles in cellular nitrogen assimilation. Although GS
active-site formation requires the oligomerization of just two GS subunits, all GS form large …

PII signal transduction proteins are widely spread among all domains of life where they
regulate a multitude of carbon and nitrogen metabolism related processes. Non-diazotrophic …

Carbon dioxide is an omnipresent gas that drives adaptive responses within organisms from
all domains of life. The molecular mechanisms by which proteins serve as sensors of CO2 …

PII, a homotrimeric very ancient and highly widespread (bacteria, archaea, plants) key
sensor-transducer protein, conveys signals of abundance or poorness of carbon, energy …

The cyclic dimeric AMP nucleotide c-di-AMP is an essential second messenger in Bacillus
subtilis. We have identified the protein DarA as one of the prominent c-di-AMP receptors in …

Coordinated carbon and nitrogen metabolism is crucial for bacteria living in the fluctuating
environments. Intracellular carbon and nitrogen homeostasis is maintained by a …