Wall shear stress and its role in atherosclerosis

M Zhou, Y Yu, R Chen, X Liu, Y Hu, Z Ma… - Frontiers in …, 2023 - frontiersin.org
Atherosclerosis (AS) is the major form of cardiovascular disease and the leading cause of
morbidity and mortality in countries around the world. Atherosclerosis combines the …

[HTML][HTML] Platelet secretion: From haemostasis to wound healing and beyond

EM Golebiewska, AW Poole - Blood reviews, 2015 - Elsevier
Upon activation, platelets secrete more than 300 active substances from their intracellular
granules. Platelet dense granule components, such as ADP and polyphosphates, contribute …

Expert recommendations on the assessment of wall shear stress in human coronary arteries: existing methodologies, technical considerations, and clinical …

F Gijsen, Y Katagiri, P Barlis, C Bourantas… - European heart …, 2019 - academic.oup.com
Expert recommendations on the assessment of wall shear stress in human coronary arteries:
existing methodologies, technical considerations, and clinical applications | European Heart …

Platelet biology and function: plaque erosion vs. rupture

CC Baaten, M Nagy, W Bergmeier… - European Heart …, 2024 - academic.oup.com
The leading cause of heart disease in developed countries is coronary atherosclerosis,
which is not simply a result of ageing but a chronic inflammatory process that can lead to …

New fundamentals in hemostasis

HH Versteeg, JWM Heemskerk, M Levi… - Physiological …, 2013 - journals.physiology.org
Hemostasis encompasses the tightly regulated processes of blood clotting, platelet
activation, and vascular repair. After wounding, the hemostatic system engages a plethora of …

Deterministic lateral displacement: Challenges and perspectives

A Hochstetter, R Vernekar, RH Austin, H Becker… - ACS …, 2020 - ACS Publications
The advent of microfluidics in the 1990s promised a revolution in multiple industries from
healthcare to chemical processing. Deterministic lateral displacement (DLD) is a continuous …

Mechanical force-triggered drug delivery

Y Zhang, J Yu, HN Bomba, Y Zhu, Z Gu - Chemical reviews, 2016 - ACS Publications
Advanced drug delivery systems (DDS) enhance treatment efficacy of different therapeutics
in a dosage, spatial, and/or temporal controlled manner. To date, numerous chemical-or …

Engineered in vitro disease models

KH Benam, S Dauth, B Hassell… - Annual Review of …, 2015 - annualreviews.org
The ultimate goal of most biomedical research is to gain greater insight into mechanisms of
human disease or to develop new and improved therapies or diagnostics. Although great …

Current and future antiplatelet therapies: emphasis on preserving haemostasis

JD McFadyen, M Schaff, K Peter - Nature Reviews Cardiology, 2018 - nature.com
Antiplatelet drugs, such as aspirin, P2Y12 antagonists, and glycoprotein (GP) IIb/IIIa
inhibitors, have proved to be successful in reducing the morbidity and mortality associated …

Shear-dependent platelet aggregation: mechanisms and therapeutic opportunities

A Rana, E Westein, B Niego… - Frontiers in cardiovascular …, 2019 - frontiersin.org
Cardiovascular diseases (CVD) are the number one cause of morbidity and death
worldwide. As estimated by the WHO, the global death rate from CVD is 31% wherein, a …