For about three decades, the chemistry of cation radicals derived from organic molecules
had received a major impetus from mass spectrometry. This was because cation radicals …

This review intends not only to discuss the current possibilities to gain 100% sequence
coverage for proteins, but also to point out the critical limits to such an attempt. The aim of …

IgA nephropathy (IgAN) is the most common primary glomerulonephritis in the world.
Aberrantly glycosylated IgA1, with galactose (Gal)-deficient hinge region (HR) O-glycans …

The inclusion of preliminary chemical labeling (derivatization) in the analysis process by
such powerful and widespread methods as electrospray ionization (ESI) and matrix-assisted …

The foodborne bacterial pathogen, Campylobacter jejuni, possesses an N-linked protein
glycosylation (pgl) pathway involved in adding conserved heptasaccharides to asparagine …

The carboxyl groups of tryptic peptides were derivatized with a tertiary or quaternary amine
labeling reagent to generate more highly charged peptide ions that fragment efficiently by …

The discovery of urinary biomarkers is a main topic in clinical medicine. The development of
proteomics has rapidly changed the knowledge on urine protein composition and probably …

This important new book provides the fundamental understanding of the peptide and protein
drug delivery systems with a special focus on their nanotechnology applications. Addressing …

O-Linked glycosylation often occurs in mucin-type domains that are heavily and
heterogeneously glycosylated and are challenging to analyze. The analysis of these …

In large scale mass spectrometry-based phosphoproteomics, a current bottleneck is the
unambiguous assignment of the phosphorylation site within the peptide. An additional …