Antibiotic resistance is currently one of the most important public health problems. The
golden age of antibiotic discovery ended decades ago, and new approaches are urgently …

Introduction The resistance-nodulation-division (RND) family is the most important group of
multidrug efflux pumps in Gram-negative bacteria. Their inhibition increases the …

Collateral sensitivity (CS) is an evolutionary trade-off traditionally linked to the mutational
acquisition of antibiotic resistance (AR). However, AR can be temporally induced, and the …

Antibiotic resistance is a major challenge in the clinical treatment of bacterial infectious
diseases. Herein, we constructed a multifunctional DNA nanoplatform as a versatile carrier …

Multidrug-resistant (MDR) bacteria-caused infections have been a major threat to human
health. The abuse of conventional antibiotics accelerates the generation of MDR bacteria …

The swift rise of antibiotic resistance, coupled with limited new antibiotic discovery, presents
a significant hurdle to global public health, demanding innovative therapeutic solutions …

By acquiring or evolving resistance to one antibiotic, bacteria can become cross-resistant to
a second antibiotic, which further limits therapeutic choices. In the opposite scenario, initial …

While the rise of antibiotic resistance poses a global health challenge, the development of
new antibiotics has slowed down over the past decades. This turned the attention of …

Pseudomonas aeruginosa is an opportunistic human pathogen that usually causes difficult-
to-treat infections due to its low intrinsic antibiotic susceptibility and outstanding capacity for …

Antibiotic resistance is one of most important health concerns nowadays, and β-lactamases
are the most important resistance determinants. These enzymes, based on their structural …