Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms

TL Liu, S Upadhyayula, DE Milkie, V Singh, K Wang… - Science, 2018 - science.org
INTRODUCTION Organisms live by means of the complex, dynamic, three-dimensional (3D)
interplay between millions of components, from the molecular to the multicellular. Visualizing …

Zebrafish–the Neurobehavioural model in trend

R Mrinalini, T Tamilanban, VN Kumar, K Manasa - Neuroscience, 2023 - Elsevier
Zebrafish (Danio rerio) is currently in vogue as a prevalently used experimental model for
studies concerning neurobehavioural disorders and associated fields. Since the 1960s, this …

A bioelectrical phase transition patterns the first vertebrate heartbeats

BZ Jia, Y Qi, JD Wong-Campos, SG Megason… - Nature, 2023 - nature.com
A regular heartbeat is essential to vertebrate life. In the mature heart, this function is driven
by an anatomically localized pacemaker. By contrast, pacemaking capability is broadly …

Extracellular hyaluronate pressure shaped by cellular tethers drives tissue morphogenesis

A Munjal, E Hannezo, TYC Tsai, TJ Mitchison… - Cell, 2021 - cell.com
How tissues acquire complex shapes is a fundamental question in biology and regenerative
medicine. Zebrafish semicircular canals form from invaginations in the otic epithelium (buds) …

Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy

F Aguet, S Upadhyayula, R Gaudin… - Molecular biology of …, 2016 - Am Soc Cell Biol
Membrane remodeling is an essential part of transferring components to and from the cell
surface and membrane-bound organelles and for changes in cell shape, which are …

Methods to study the development, anatomy, and function of the zebrafish inner ear across the life course

S Baxendale, TT Whitfield - Methods in cell biology, 2016 - Elsevier
The inner ear is a remarkably intricate structure able to detect sound, motion, and gravity.
During development of the zebrafish embryo, the ear undergoes dynamic morphogenesis …

Developmental exposure to environmental levels of cadmium induces neurotoxicity and activates microglia in zebrafish larvae: From the perspectives of …

Y Xu, H Zhao, Z Wang, H Gao, J Liu, K Li, Z Song… - Chemosphere, 2022 - Elsevier
Cadmium (Cd) is a worldwide environmental pollutant that postures serious threats to
humans and ecosystems. Over the years, its adverse effects on the central nervous system …

Sheath cell invasion and trans-differentiation repair mechanical damage caused by loss of caveolae in the zebrafish notochord

J Garcia, J Bagwell, B Njaine, J Norman, DS Levic… - Current Biology, 2017 - cell.com
The notochord, a conserved axial structure required for embryonic axis elongation and spine
development, consists of giant vacuolated cells surrounded by an epithelial sheath [1–3] …

Zebrafish imaging reveals TP53 mutation switching oncogene-induced senescence from suppressor to driver in primary tumorigenesis

Y Haraoka, Y Akieda, Y Nagai, C Mogi… - Nature …, 2022 - nature.com
Most tumours are thought to arise through oncogenic cell generation followed by additional
mutations. How a new oncogenic cell primes tumorigenesis by acquiring additional …