Severe cases of COVID-19 are characterized by hyperinflammation induced by cytokine
storm, ARDS leading to multiorgan failure and death. JAK-STAT signaling has been …

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) is an intricate
signaling cascade composed of various cytokines, interferons (IFN, growth factors, and other …

With an epidemic spread, metabolic syndrome represents an increasingly emerging risk for
the population globally, and is currently recognized as a pathological entity. It is represented …

Polyadenosine diphosphate‐ribose polymerase 7 (PARP7) acts as a suppressor of the type
I interferon (IFN) signaling pathway via suppressing TANK‐binding protein 1 (TBK1) …

The COVID-19 pandemic, instigated by the emergence of the novel coronavirus, SARS-CoV-
2, created an incomparable global health crisis. Due to its highly virulent nature, identifying …

Coronaviruses, including SARS-CoV-2, have caused pandemics in the past two decades.
The most prevalent SARS-CoV-2 variants of concern can re-infect individuals who have …

The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway
functions as a central hub for transmitting signals from more than 50 cytokines, playing a …

The severe acquired respiratory coronavirus–2 (SARS–CoV-2) infection has initiated both
acute and chronic COVID–19 disease between 2020 and 2023, currently evolving with other …

Abstract Background: Coronavirus disease 2019 (COVID-19), is more severe in individuals
with obesity. Furthermore, a cytokine storm was observed in many critically ill patients with …

The SARS–CoV-2 infection has caused both acute and chronic COVID–19 disease during
the recent pandemic with emerging more transmissible SARS–CoV–2 Omicron variants …