Thiazolidinediones (TZDs) are potent insulin sensitizers that act through the nuclear
receptor peroxisome proliferator-activated receptor-γ (PPARγ) and are highly effective oral …

Essential fatty acids (EFAs), linoleic acid (LA), and α‐linolenic acid (ALA) are essential for
humans, and are freely available in the diet. Hence, EFA deficiency is extremely rare in …

Insulin resistance in muscle and liver and-cell failure represent the core pathophysiologic
defects in type 2 diabetes. It now is recognized that the-cell failure occurs much earlier and …

Two general approaches to the treatment of type 2 diabetes mellitus (T2DM) have been
advocated. 1) A “guideline” approach that advocates sequential addition of antidiabetes …

▪ Abstract The metabolic nuclear receptors act as metabolic and toxicological sensors,
enabling the organism to quickly adapt to environmental changes by inducing the …

Essential fatty acids (EFAs): cis-linoleic acid (LA) and-linolenic acid (ALA) are essential for
humans and their deficiency is rare in humans due to their easy availability in diet. EFAs are …

Type 2 diabetes develops in the context of both insulin resistance and β-cell failure.
Thiazolidinediones are a class of antidiabetic agents that are known to improve insulin …

The peroxisome proliferator-activated receptor γ (PPARγ) is a prototypical member of the
nuclear receptor superfamily and integrates the control of energy, lipid, and glucose …

Thiazolidinediones (TZDs) improve glycemic control and insulin sensitivity in patients with
type 2 diabetes mellitus (T2DM). There is growing evidence from in vivo and in vitro studies …

Peroxisome proliferator–activated receptors (PPARs) form a family of nuclear hormone
receptors involved in energy hemostasis and lipid metabolism (1, 2) and include three …