Circulating platelets as mediators of immunity, inflammation, and thrombosis
M Koupenova, L Clancy, HA Corkrey… - Circulation …, 2018 - Am Heart Assoc
Platelets, non-nucleated blood components first described over 130 years ago, are
recognized as the primary cell regulating hemostasis and thrombosis. The vascular …
recognized as the primary cell regulating hemostasis and thrombosis. The vascular …
Platelets and the immune continuum
Platelets are anucleate cells that are crucial mediators of haemostasis. Most immunologists
probably don't think about platelets every day, and may even consider these cells to …
probably don't think about platelets every day, and may even consider these cells to …
Platelets can associate with SARS-Cov-2 RNA and are hyperactivated in COVID-19
Rationale: In addition to the overwhelming lung inflammation that prevails in coronavirus
disease 2019 (COVID-19), hypercoagulation and thrombosis contribute to the lethality of …
disease 2019 (COVID-19), hypercoagulation and thrombosis contribute to the lethality of …
[HTML][HTML] RNA-Seq of tumor-educated platelets enables blood-based pan-cancer, multiclass, and molecular pathway cancer diagnostics
Tumor-educated blood platelets (TEPs) are implicated as central players in the systemic and
local responses to tumor growth, thereby altering their RNA profile. We determined the …
local responses to tumor growth, thereby altering their RNA profile. We determined the …
Platelet activation and atherothrombosis
This review of the role of platelets in atherothrombosis illuminates the surprisingly numerous
activities of these tiny, anucleate cells and stresses their participation in the inflammatory …
activities of these tiny, anucleate cells and stresses their participation in the inflammatory …
Emerging roles for platelets as immune and inflammatory cells
CN Morrell, AA Aggrey, LM Chapman… - Blood, The Journal of …, 2014 - ashpublications.org
Despite their small size and anucleate status, platelets have diverse roles in vascular
biology. Not only are platelets the cellular mediator of thrombosis, but platelets are also …
biology. Not only are platelets the cellular mediator of thrombosis, but platelets are also …
Function of alternative splicing
Almost all polymerase II transcripts undergo alternative pre-mRNA splicing. Here, we review
the functions of alternative splicing events that have been experimentally determined. The …
the functions of alternative splicing events that have been experimentally determined. The …
Platelets, inflammation and tissue regeneration
AT Nurden - Thrombosis and haemostasis, 2011 - thieme-connect.com
Blood platelets have long been recognised to bring about primary haemostasis with
deficiencies in platelet production and function manifesting in bleeding while upregulated …
deficiencies in platelet production and function manifesting in bleeding while upregulated …
Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation
LH Boudreau, AC Duchez, N Cloutier… - Blood, The Journal …, 2014 - ashpublications.org
Mitochondrial DNA (mtDNA) is a highly potent inflammatory trigger and is reportedly found
outside the cells in blood in various pathologies. Platelets are abundant in blood where they …
outside the cells in blood in various pathologies. Platelets are abundant in blood where they …
Platelets as key factors in inflammation: focus on CD40L/CD40
F Cognasse, AC Duchez, E Audoux… - Frontiers in …, 2022 - frontiersin.org
Platelets are anucleate cytoplasmic fragments derived from the fragmentation of medullary
megakaryocytes. Activated platelets adhere to the damaged endothelium by means of …
megakaryocytes. Activated platelets adhere to the damaged endothelium by means of …