PIWI-interacting RNAs: small RNAs with big functions

DM Ozata, I Gainetdinov, A Zoch, D O'Carroll… - Nature Reviews …, 2019 - nature.com
In animals, PIWI-interacting RNAs (piRNAs) of 21–35 nucleotides in length silence
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …

piRNA-guided genome defense: from biogenesis to silencing

B Czech, M Munafò, F Ciabrelli… - Annual review of …, 2018 - annualreviews.org
PIWI-interacting RNAs (piRNAs) and their associated PIWI clade Argonaute proteins
constitute the core of the piRNA pathway. In gonadal cells, this conserved pathway is crucial …

One loop to rule them all: the **-pong cycle and piRNA-guided silencing

B Czech, GJ Hannon - Trends in biochemical sciences, 2016 - cell.com
The PIWI-interacting RNA (piRNA) pathway is a conserved defense mechanism that protects
the genetic information of animal germ cells from the deleterious effects of molecular …

PIWI-interacting RNA: its biogenesis and functions

YW Iwasaki, MC Siomi, H Siomi - Annual review of biochemistry, 2015 - annualreviews.org
PIWI-interacting RNAs (piRNAs) are a class of small RNAs that are 24–31 nucleotides in
length. They associate with PIWI proteins, which constitute a germline-specific subclade of …

piRNA-guided transposon cleavage initiates Zucchini-dependent, phased piRNA production

BW Han, W Wang, C Li, Z Weng, PD Zamore - Science, 2015 - science.org
PIWI-interacting RNAs (piRNAs) protect the animal germ line by silencing transposons.
Primary piRNAs, generated from transcripts of genomic transposon “junkyards”(piRNA …

Triacylglycerol Metabolism in Drosophila melanogaster

C Heier, RP Kühnlein - Genetics, 2018 - academic.oup.com
Triacylglycerol (TAG) is the most important caloric source with respect to energy
homeostasis in animals. In addition to its evolutionarily conserved importance as an energy …

The piRNA pathway guards the germline genome against transposable elements

KF Tóth, D Pezic, E Stuwe, A Webster - Non-coding RNA and the …, 2016 - Springer
Transposable elements (TEs) have the capacity to replicate and insert into new genomic
locations. This contributs significantly to evolution of genomes, but can also result in DNA …

Panoramix enforces piRNA-dependent cotranscriptional silencing

Y Yu, J Gu, Y **, Y Luo, JB Preall, J Ma, B Czech… - Science, 2015 - science.org
The Piwi-interacting RNA (piRNA) pathway is a small RNA–based innate immune system
that defends germ cell genomes against transposons. In Drosophila ovaries, the nuclear …

piRNA Biogenesis in Drosophila melanogaster

X Huang, KF Tóth, AA Aravin - Trends in Genetics, 2017 - cell.com
The PIWI-interacting RNA (piRNA) pathway is a conserved defense system that protects the
genome integrity of the animal germline from deleterious transposable elements. Targets of …

Posttranscriptional regulation of gene expression by Piwi proteins and piRNAs

T Watanabe, H Lin - Molecular cell, 2014 - cell.com
Piwi proteins and Piwi-interacting RNAs (piRNAs) are essential for gametogenesis,
embryogenesis, and stem cell maintenance in animals. Piwi proteins act on transposon …