Gut microbiota in colorectal cancer development and therapy

CC Wong, J Yu - Nature Reviews Clinical Oncology, 2023 - nature.com
Colorectal cancer (CRC) is one of the commonest cancers globally. A unique aspect of CRC
is its intimate association with the gut microbiota, which forms an essential part of the tumour …

Human gut microbiota in health and disease: Unveiling the relationship

M Afzaal, F Saeed, YA Shah, M Hussain… - Frontiers in …, 2022 - frontiersin.org
The human gut possesses millions of microbes that define a complex microbial community.
The gut microbiota has been characterized as a vital organ forming its multidirectional …

Targeting the gut and tumor microbiota in cancer

EM Park, M Chelvanambi, N Bhutiani, G Kroemer… - Nature medicine, 2022 - nature.com
Microorganisms within the gut and other niches may contribute to carcinogenesis, as well as
sha** cancer immunosurveillance and response to immunotherapy. Our understanding of …

The IL-17 family in diseases: from bench to bedside

L Huangfu, R Li, Y Huang, S Wang - Signal transduction and targeted …, 2023 - nature.com
Abstract The interleukin-17 (IL-17) family comprises six members (IL-17A–17F), and
recently, all of its related receptors have been discovered. IL-17 was first discovered …

Colorectal cancer in inflammatory bowel disease: mechanisms and management

SC Shah, SH Itzkowitz - Gastroenterology, 2022 - Elsevier
Patients with inflammatory bowel disease (IBD) are at increased risk of develo**
colorectal cancer (CRC), despite decreases in CRC incidence in recent years. Chronic …

Role of the gut microbiota and its metabolites in tumorigenesis or development of colorectal cancer

R Qu, Y Zhang, Y Ma, X Zhou, L Sun, C Jiang… - Advanced …, 2023 - Wiley Online Library
Colorectal cancer (CRC) is the most common cancer of the digestive system with high
mortality and morbidity rates. Gut microbiota is found in the intestines, especially the …

The inflammatory pathogenesis of colorectal cancer

M Schmitt, FR Greten - Nature Reviews Immunology, 2021 - nature.com
The mutational landscape of colorectal cancer (CRC) does not enable predictions to be
made about the survival of patients or their response to therapy. Instead, studying the …

Intratumoural microbiota: a new frontier in cancer development and therapy

Y Cao, H **a, X Tan, C Shi, Y Ma, D Meng… - … and Targeted Therapy, 2024 - nature.com
Human microorganisms, including bacteria, fungi, and viruses, play key roles in several
physiological and pathological processes. Some studies discovered that tumour tissues …

Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications

LY Zhao, JX Mei, G Yu, L Lei, WH Zhang… - … and Targeted Therapy, 2023 - nature.com
In the past period, due to the rapid development of next-generation sequencing technology,
accumulating evidence has clarified the complex role of the human microbiota in the …

The intestinal microbiota and colorectal cancer

Y Cheng, Z Ling, L Li - Frontiers in immunology, 2020 - frontiersin.org
The intestinal microbiota, composed of a large population of microorganisms, is often
considered a “forgotten organ” in human health and diseases. Increasing evidence indicates …