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Fluid transport in the brain
The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …
wakefulness, the brain is geared fully toward processing information and behaving, while …
The glymphatic system: Current understanding and modeling
We review theoretical and numerical models of the glymphatic system, which circulates
cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models …
cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models …
Small vessel disease: mechanisms and clinical implications
Small vessel disease is a disorder of cerebral microvessels that causes white matter
hyperintensities and several other common abnormalities (eg, recent small subcortical …
hyperintensities and several other common abnormalities (eg, recent small subcortical …
Perivascular spaces in the brain: anatomy, physiology and pathology
Perivascular spaces include a variety of passageways around arterioles, capillaries and
venules in the brain, along which a range of substances can move. Although perivascular …
venules in the brain, along which a range of substances can move. Although perivascular …
Pathophysiology of blood brain barrier dysfunction during chronic cerebral hypoperfusion in vascular cognitive impairment
The prevalence of cerebrovascular disease increases with age, placing the elderly at a
greater lifetime risk for dementia. Vascular cognitive impairment (VCI) encompasses a …
greater lifetime risk for dementia. Vascular cognitive impairment (VCI) encompasses a …
Vascular Cognitive Impairment and Dementia: JACC Scientific Expert Panel
Cognitive impairment associated with aging has emerged as one of the major public health
challenges of our time. Although Alzheimer's disease is the leading cause of clinically …
challenges of our time. Although Alzheimer's disease is the leading cause of clinically …
Cognitive impact of COVID-19: looking beyond the short term
COVID-19 is primarily a respiratory disease but up to two thirds of hospitalised patients show
evidence of central nervous system (CNS) damage, predominantly ischaemic, in some …
evidence of central nervous system (CNS) damage, predominantly ischaemic, in some …
Neurovascular and cognitive dysfunction in hypertension: epidemiology, pathobiology, and treatment
Hypertension has emerged as a leading cause of age-related cognitive impairment. Long
known to be associated with dementia caused by vascular factors, hypertension has more …
known to be associated with dementia caused by vascular factors, hypertension has more …
Age-related immune alterations and cerebrovascular inflammation
Aging is associated with chronic systemic inflammation, which contributes to the
development of many age-related diseases, including vascular disease. The world's …
development of many age-related diseases, including vascular disease. The world's …
New insights into cerebrovascular pathophysiology and hypertension
Despite advances in acute management and prevention of cerebrovascular disease, stroke
and vascular cognitive impairment together remain the world's leading cause of death and …
and vascular cognitive impairment together remain the world's leading cause of death and …