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Application of CRISPR/Cas9-based gene editing in HIV-1/AIDS therapy
Despite the fact that great efforts have been made in the prevention and therapy of HIV-1
infection, HIV-1/AIDS remains a major threat to global human health. Highly active …
infection, HIV-1/AIDS remains a major threat to global human health. Highly active …
Gene regulation by the act of long non-coding RNA transcription
Long non-protein-coding RNAs (lncRNAs) are proposed to be the largest transcript class in
the mouse and human transcriptomes. Two important questions are whether all lncRNAs are …
the mouse and human transcriptomes. Two important questions are whether all lncRNAs are …
HIV “shock and kill” therapy: In need of revision
The implementation of antiretroviral therapy 23 years ago has rendered HIV infection
clinically manageable. However, the disease remains incurable, since it establishes latent …
clinically manageable. However, the disease remains incurable, since it establishes latent …
Understanding HIV latency: the road to an HIV cure
Treatment with antiretroviral therapy dramatically increases the survival of HIV-infected
individuals. However, treatment has to be continued for life because it does not lead to the …
individuals. However, treatment has to be continued for life because it does not lead to the …
HIV-1 transcription and latency: an update
C Van Lint, S Bouchat, A Marcello - Retrovirology, 2013 - Springer
Combination antiretroviral therapy, despite being potent and life-prolonging, is not curative
and does not eradicate HIV-1 infection since interruption of treatment inevitably results in a …
and does not eradicate HIV-1 infection since interruption of treatment inevitably results in a …
[HTML][HTML] Transcriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cure
Replication-competent latent HIV-1 proviruses that persist in the genomes of a very small
subset of resting memory T cells in infected individuals under life-long antiretroviral therapy …
subset of resting memory T cells in infected individuals under life-long antiretroviral therapy …
The role of FACT in making and breaking nucleosomes
FACT is a roughly 180kDa heterodimeric protein complex important for managing the
properties of chromatin in eukaryotic cells. Chromatin is a repressive barrier that plays an …
properties of chromatin in eukaryotic cells. Chromatin is a repressive barrier that plays an …
Different human resting memory CD4+ T cell subsets show similar low inducibility of latent HIV-1 proviruses
The latent reservoir of HIV-1 in resting CD4+ T cells is a major barrier to cure. It is unclear
whether the latent reservoir resides principally in particular subsets of CD4+ T cells, a …
whether the latent reservoir resides principally in particular subsets of CD4+ T cells, a …
The chromatin landscape at the HIV-1 provirus integration site determines viral expression
HIV-1 persists lifelong in memory cells of the immune system as latent provirus that
rebounds upon treatment interruption. Therefore, the latent reservoir is the main target for an …
rebounds upon treatment interruption. Therefore, the latent reservoir is the main target for an …
Cellular and molecular mechanisms involved in the establishment of HIV-1 latency
DA Donahue, MA Wainberg - Retrovirology, 2013 - Springer
Latently infected cells represent the major barrier to either a sterilizing or a functional HIV-1
cure. Multiple approaches to reactivation and depletion of the latent reservoir have been …
cure. Multiple approaches to reactivation and depletion of the latent reservoir have been …