Cardiac arrhythmias are among the leading causes of mortality. They often arise from
alterations in the electrophysiological properties of cardiac cells and their underlying ionic …

The heart is vital for biological function in almost all chordates, including humans. It beats
continually throughout our life, supplying the body with oxygen and nutrients while removing …

Mechanical forces will have been omnipresent since the origin of life, and living organisms
have evolved mechanisms to sense, interpret, and respond to mechanical stimuli. The …

Background—Antiarrhythmic management of atrial fibrillation (AF) remains a major clinical
challenge. Mechanism-based approaches to AF therapy are sought to increase …

Cardiac fibroblasts (CF) play a pivotal role in preserving myocardial function and integrity of
the heart tissue after injury, but also contribute to future susceptibility to heart failure. CF …

Aims Atrial fibrillation (AF) is associated with tachycardia-induced cellular electrophysiology
alterations which promote AF chronification and treatment resistance. Development of novel …

Two-pore-domain potassium (K2P-) channels conduct outward K+ currents that maintain the
resting membrane potential and modulate action potential repolarization. Members of the …

The pacemaker cells of the cardiac sinoatrial node (SAN) are essential for normal cardiac
automaticity. Dysfunction in cardiac pacemaking results in human sinoatrial node …

Human pluripotent stem cell-derived cardiomyocytes (PSC-CMs) have great potential
application in almost all areas of cardiovascular research. A current major goal of the field is …

Cardiac fibrosis is defined as excessive deposition of extracellular matrix (ECM) in
pathological conditions. Cardiac fibroblasts (CFs) activated by injury or inflammation …