Shining new light on biological systems: luminescent transition metal complexes for bioimaging and biosensing applications

LCC Lee, KKW Lo - Chemical Reviews, 2024 - ACS Publications
Luminescence imaging is a powerful and versatile technique for investigating cell
physiology and pathology in living systems, making significant contributions to life science …

[HTML][HTML] Amyloid β, Tau, and α-Synuclein aggregates in the pathogenesis, prognosis, and therapeutics for neurodegenerative diseases

U Sengupta, R Kayed - Progress in neurobiology, 2022 - Elsevier
Aggregation of specific proteins are histopathological hallmarks of several
neurodegenerative diseases, such as, Amyloid β (Aβ) plaques and tau neurofibrillary …

Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing

S Alberti, AA Hyman - Nature reviews Molecular cell biology, 2021 - nature.com
Biomolecular condensates are membraneless intracellular assemblies that often form via
liquid− liquid phase separation and have the ability to concentrate biopolymers. Research …

The proteostasis network and its decline in ageing

MS Hipp, P Kasturi, FU Hartl - Nature reviews Molecular cell biology, 2019 - nature.com
Ageing is a major risk factor for the development of many diseases, prominently including
neurodegenerative disorders such as Alzheimer disease and Parkinson disease. A hallmark …

Ageing exacerbates ribosome pausing to disrupt cotranslational proteostasis

KC Stein, F Morales-Polanco, J van der Lienden… - Nature, 2022 - nature.com
Ageing is accompanied by a decline in cellular proteostasis, which underlies many age-
related protein misfolding diseases,. Yet, how ageing impairs proteostasis remains unclear …

Inflammasomes as therapeutic targets in human diseases

Y Li, H Huang, B Liu, Y Zhang, X Pan, XY Yu… - Signal transduction and …, 2021 - nature.com
Inflammasomes are protein complexes of the innate immune system that initiate
inflammation in response to either exogenous pathogens or endogenous danger signals …

Food protein amyloid fibrils: Origin, structure, formation, characterization, applications and health implications

Y Cao, R Mezzenga - Advances in colloid and interface science, 2019 - Elsevier
Amyloid fibrils have traditionally been considered only as pathological aggregates in human
neurodegenerative diseases, but it is increasingly becoming clear that the propensity to form …

Amyloid nomenclature 2018: recommendations by the International Society of Amyloidosis (ISA) nomenclature committee

MD Benson, JN Buxbaum, DS Eisenberg, G Merlini… - Amyloid, 2018 - Taylor & Francis
The nomenclature committee of the International Society of Amyloidosis (ISA) meets every
second year to discuss and formulate recommendations. The conclusions from the …

Protein-stabilized Pickering emulsions: Formation, stability, properties, and applications in foods

X Yan, C Ma, F Cui, DJ McClements, X Liu… - Trends in Food Science & …, 2020 - Elsevier
Background Pickering emulsions prepared using food-grade colloidal particles can be
designed to have high physical stability, tunable textural attributes, and good …

Amyloid-type protein aggregation and prion-like properties of amyloids

D Willbold, B Strodel, GF Schröder, W Hoyer… - Chemical …, 2021 - ACS Publications
This review will focus on the process of amyloid-type protein aggregation. Amyloid fibrils are
an important hallmark of protein misfolding diseases and therefore have been investigated …