Tissue response to neural implants: the use of model systems toward new design solutions of implantable microelectrodes
The development of implantable neuroelectrodes is advancing rapidly as these tools are
becoming increasingly ubiquitous in clinical practice, especially for the treatment of …
becoming increasingly ubiquitous in clinical practice, especially for the treatment of …
[HTML][HTML] Astrocytogenesis: where, when, and how
Astrocytes are the most abundant cell type in the central nervous system and have diverse
functions in blood–brain barrier maintenance, neural circuitry formation and function, and …
functions in blood–brain barrier maintenance, neural circuitry formation and function, and …
Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer's disease
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative diseases, yet
current therapeutic treatments are inadequate due to a complex disease pathogenesis. The …
current therapeutic treatments are inadequate due to a complex disease pathogenesis. The …
Natural variation in gene expression and viral susceptibility revealed by neural progenitor cell villages
Human genome variation contributes to diversity in neurodevelopmental outcomes and
vulnerabilities; recognizing the underlying molecular and cellular mechanisms will require …
vulnerabilities; recognizing the underlying molecular and cellular mechanisms will require …
Mimicking human pathophysiology in organ‐on‐chip devices
Convergence of life sciences, engineering, and basic sciences has opened new horizons for
biologically inspired innovations, and a considerable number of organ‐on‐a‐chip platforms …
biologically inspired innovations, and a considerable number of organ‐on‐a‐chip platforms …
Impairments in motor neurons, interneurons and astrocytes contribute to hyperexcitability in ALS: underlying mechanisms and paths to therapy
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterised by
the loss of motor neurons leading to progressive paralysis and death. Using transcranial …
the loss of motor neurons leading to progressive paralysis and death. Using transcranial …
Dopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects
L Borgs, E Peyre, P Alix, K Hanon, B Grobarczyk… - Scientific reports, 2016 - nature.com
Some mutations of the LRRK2 gene underlie autosomal dominant form of Parkinson's
disease (PD). The G2019S is a common mutation that accounts for about 2% of PD cases …
disease (PD). The G2019S is a common mutation that accounts for about 2% of PD cases …
A simple differentiation protocol for generation of induced pluripotent stem cell-derived basal forebrain-like cholinergic neurons for Alzheimer's disease and …
The study of neurodegenerative diseases using pluripotent stem cells requires new methods
to assess neurodevelopment and neurodegeneration of specific neuronal subtypes. The …
to assess neurodevelopment and neurodegeneration of specific neuronal subtypes. The …
Using patient-derived induced pluripotent stem cells to identify Parkinson's disease-relevant phenotypes
Abstract Purpose of Review Parkinson's disease (PD) is the second most common
neurodegenerative disorder affecting older individuals. The specific cause underlying …
neurodegenerative disorder affecting older individuals. The specific cause underlying …
Photobiomodulation with a 660-nanometer light-emitting diode promotes cell proliferation in astrocyte culture
Astrocytes act as neural stem cells (NSCs) that have the potential to self-renew and
differentiate into other neuronal cells. The protein expression of these astrocytes depends …
differentiate into other neuronal cells. The protein expression of these astrocytes depends …