Formal [4+ 1] annulation reactions in the synthesis of carbocyclic and heterocyclic systems

JR Chen, XQ Hu, LQ Lu, WJ **ao - Chemical reviews, 2015 - ACS Publications
The development of new strategies and chemical reactions continues to be a major focus of
research efforts in the modern synthetic organic community. 1 Of the various types of …

Recent advances in the chemistry of conjugated nitrosoalkenes and azoalkenes

SMM Lopes, AL Cardoso, A Lemos… - Chemical …, 2018 - ACS Publications
This review aims to present the most recent contributions in the chemistry of nitrosoalkenes
and azoalkenes, highlighting the chemical behavior that makes them important and versatile …

Formal [4+1] Annulation of Azoalkenes with CF3-Imidoyl Sulfoxonium Ylides and Dual Double Bond Isomerization Cascade: Synthesis of Trifluoromethyl-Containing …

Y Sun, Z Yang, SN Lu, Z Chen, XF Wu - Organic Letters, 2022 - ACS Publications
A straightforward strategy for the metal-free construction of trifluoromethyl-containing
pyrazole derivatives has been achieved from readily available α-halo hydrazones and CF3 …

N-heterocyclic carbene catalyzed switchable reactions of enals with azoalkenes: formal [4+ 3] and [4+ 1] annulations for the synthesis of 1, 2-diazepines and pyrazoles

C Guo, B Sahoo, CG Daniliuc… - Journal of the American …, 2014 - ACS Publications
A regio-and enantioselective formal [4+ 3] annulation reaction between enals and in situ
formed azoalkenes has been achieved. A diverse set of 1, 2-diazepine derivatives were …

I2/TBPB Mediated Oxidative Reaction of N-Tosylhydrazones with Anilines: Practical Construction of 1,4-Disubstituted 1,2,3-Triazoles under Metal-Free and Azide …

ZJ Cai, XM Lu, Y Zi, C Yang, LJ Shen, J Li… - Organic …, 2014 - ACS Publications
An efficient I2 (20 mol%)/TBPB mediated oxidative formal [4+ 1] cycloaddition of N-
tosylhydrazones with anilines via C–N/N–N bond formation and S–N cleavage has been …

Enantioselective synthesis of multi-nitrogen-containing heterocycles using azoalkenes as key intermediates

L Wei, C Shen, YZ Hu, HY Tao, CJ Wang - Chemical Communications, 2019 - pubs.rsc.org
Chiral multi-nitrogen-containing heterocycles, such as pyrazole, imidazole and pyridazine,
are widely found in naturally occurring organic compounds and pharmaceuticals, and …

Chemo-, regio-and enantioselective dearomative (3+ 2) reaction of non-functionalized 1-naphthols

GJ Mei, Y Luo, WL Koay, R Li, Y Lan, Y Lu - Chem Catalysis, 2022 - cell.com
The catalytic asymmetric dearomatization reaction of non-functionalized arenes poses a
long-standing synthetic challenge to organic chemists because of the relative ease of …

Catalytic asymmetric cascade vinylogous Mukaiyama 1, 6-Michael/Michael addition of 2-silyloxyfurans with azoalkenes: direct approach to fused butyrolactones

J Li, R Huang, YK **ng, G Qiu, HY Tao… - Journal of the American …, 2015 - ACS Publications
An unprecedented cascade vinylogous Mukaiyama 1, 6-MA/MA of 2-silyloxyfurans and
azoalkenes was realized with a Cu (II)/t Bu-Box complex. An array of fused butyrolactones …

Synthesis of 5-(trifluoromethyl) pyrazolines by formal [4+ 1]-annulation of fluorinated sulfur ylides and azoalkenes

Z Wang, Y Yang, F Gao, Z Wang, Q Luo, L Fang - Organic letters, 2018 - ACS Publications
Synthesis of 5-(Trifluoromethyl)pyrazolines by Formal [4 + 1]-Annulation of Fluorinated Sulfur
Ylides and Azoalkenes | Organic Letters ACS ACS Publications C&EN CAS Find my institution …

TEMPO-mediated aza-Diels–Alder reaction: Synthesis of tetrahydropyridazines using ketohydrazones and olefins

XL Yang, XX Peng, F Chen, B Han - Organic letters, 2016 - ACS Publications
A novel, facile, and efficient method for the synthesis of tetrahydropyridazines by a one-pot
tandem reaction of easily accessible ketohydrazones and olefins in the presence of 2, 2, 6, 6 …