Border control: regulating LPS biogenesis
RL Guest, ST Rutherford, TJ Silhavy - Trends in Microbiology, 2021 - cell.com
The outer membrane (OM) is a defining feature of Gram-negative bacteria that serves as a
permeability barrier and provides rigidity to the cell. Critical to OM function is establishing …
permeability barrier and provides rigidity to the cell. Critical to OM function is establishing …
Advances in therapeutic bacterial antisense biotechnology
Antisense therapeutics are a biotechnological form of antibiotic therapy using chemical
analogues of short single-stranded nucleic acid sequences modified to form stable …
analogues of short single-stranded nucleic acid sequences modified to form stable …
Structure of the essential inner membrane lipopolysaccharide–PbgA complex
Lipopolysaccharide (LPS) resides in the outer membrane of Gram-negative bacteria where it
is responsible for barrier function,. LPS can cause death as a result of septic shock, and its …
is responsible for barrier function,. LPS can cause death as a result of septic shock, and its …
Global landscape of cell envelope protein complexes in Escherichia coli
Bacterial cell envelope protein (CEP) complexes mediate a range of processes, including
membrane assembly, antibiotic resistance and metabolic coordination. However, only …
membrane assembly, antibiotic resistance and metabolic coordination. However, only …
YejM modulates activity of the YciM/FtsH protease complex to prevent lethal accumulation of lipopolysaccharide
RL Guest, D Samé Guerra, M Wissler, J Grimm… - MBio, 2020 - Am Soc Microbiol
Lipopolysaccharide (LPS) is an essential glycolipid present in the outer membrane (OM) of
many Gram-negative bacteria. Balanced biosynthesis of LPS is critical for cell viability; too …
many Gram-negative bacteria. Balanced biosynthesis of LPS is critical for cell viability; too …
An essential membrane protein modulates the proteolysis of LpxC to control lipopolysaccharide synthesis in Escherichia coli
EM Fivenson, TG Bernhardt - MBio, 2020 - Am Soc Microbiol
Gram-negative bacteria are surrounded by a complex cell envelope that includes two
membranes. The outer membrane prevents many drugs from entering these cells and is thus …
membranes. The outer membrane prevents many drugs from entering these cells and is thus …
Targeting bacterial cardiolipin enriched microdomains: an antimicrobial strategy used by amphiphilic aminoglycoside antibiotics
M El Khoury, J Swain, G Sautrey, L Zimmermann… - Scientific reports, 2017 - nature.com
Some bacterial proteins involved in cell division and oxidative phosphorylation are tightly
bound to cardiolipin. Cardiolipin is a non-bilayer anionic phospholipid found in bacterial …
bound to cardiolipin. Cardiolipin is a non-bilayer anionic phospholipid found in bacterial …
Structural and functional insights into the lipopolysaccharide ABC transporter LptB2FG
H Dong, Z Zhang, X Tang, NG Paterson… - Nature …, 2017 - nature.com
The cell surface of most Gram-negative bacteria contains lipopolysaccharide that is
essential for their viability and drug resistance. A 134-kDa protein complex LptB2FG is …
essential for their viability and drug resistance. A 134-kDa protein complex LptB2FG is …
YejM controls LpxC levels by regulating protease activity of the FtsH/YciM complex of Escherichia coli
LpxC is a deacetylase that catalyzes the first committed step of lipid A biosynthesis in
Escherichia coli. LpxC competes for a common precursor, R-3-hydroxymyristoyl-UDP …
Escherichia coli. LpxC competes for a common precursor, R-3-hydroxymyristoyl-UDP …
Regulation of the first committed step in lipopolysaccharide biosynthesis catalyzed by LpxC requires the essential protein LapC (YejM) and HslVU protease
We previously showed that lipopolysaccharide (LPS) assembly requires the essential LapB
protein to regulate FtsH-mediated proteolysis of LpxC protein that catalyzes the first …
protein to regulate FtsH-mediated proteolysis of LpxC protein that catalyzes the first …