Cancer researchers have traditionally used the mouse and the rat as staple model
organisms. These animals are very short-lived, reproduce rapidly and are highly prone to …

Hyaluronic acid (HA) is a linear polysaccharide and crucial component of the extracellular
matrix (ECM), maintaining tissue hydration and tension. Moreover, HA contributes to …

Aging negatively impacts vitality and health. Many genetic pathways that regulate aging
were discovered in invertebrates. However, the genetics of aging is more complex in …

Bats are distinctive among mammals due to their ability to fly, use laryngeal echolocation,
and tolerate viruses. However, there are currently no reliable cellular models for studying bat …

The naked mole‐rat (Heterocephalus glaber) has fascinated zoologists for at least half a
century. It has also generated considerable biomedical interest not only because of its …

Naked mole-rats (NMRs, Heterocephalus glaber) are the longest-lived rodents with a
maximum life span exceeding 37 years. They exhibit a delayed aging phenotype and …

Neural cultures derived from Huntington's disease (HD) patient-derived induced pluripotent
stem cells were used for'omics' analyses to identify mechanisms underlying …

Aging is a nearly inescapable trait among organisms yet lifespan varies tremendously
across different species and spans several orders of magnitude in vertebrates alone. This …

Abstract Naked mole-rat (NMR), the longest-living rodent, produces very-high-molecular-
mass hyaluronan (vHMM-HA), compared to other mammalian species. However, it is …

In the long-lived naked mole-rat (NMR), the entire process of oogenesis occurs postnatally.
Germ cell numbers increase significantly in NMRs between postnatal days 5 (P5) and P8 …