Glioblastoma (GBM) is the most prevalent malignant primary brain tumor, accounting for
14.2% of all diagnosed tumors and 50.1% of all malignant tumors, and the median survival …

Disruption of circadian clocks is strongly associated with mood disorders. Chronotherapies
targeting circadian rhythms have been shown to be very effective treatments of mood …

Reperfusion of patients after myocardial infarction (heart attack) triggers cardiac
inflammation that leads to infarct expansion and heart failure (HF). We previously showed …

The circadian mechanism underlies daily rhythms in cardiovascular physiology and rhythm
disruption is a major risk factor for heart disease and worse outcomes. However, the role of …

REV-ERBs are atypical nuclear receptors as they function as ligand-regulated
transcriptional repressors. The natural ligand for the REV-ERBs (REV-ERBα and REV …

Cell-autonomous circadian clocks have emerged as temporal orchestrators of numerous
biological processes. For example, the cardiomyocyte circadian clock modulates …

Circadian rhythm is a universal life phenomenon that plays an important role in maintaining
the multiple physiological functions and regulating the adaptability to internal and external …

Environmental disruption of the circadian rhythm is linked with increased pain due to
osteoarthritis (OA). We aimed to characterize the role of the clock gene in OA-induced pain …

The circadian clock is a biochemical oscillator that rhythmically regulates physiological and
behavioral processes such as inflammation, immunity, and metabolism in mammals …

Backgrounds: The circadian clock protein Rev-erbα is a crucial regulator of circadian
rhythms that affects multiple molecular, cellular, and physiology pathways that control …