The field of human microbiome research has revealed the intimate co-association of
humans with diverse communities of microbes in various habitats in the human body, and …

Genomic studies feature multivariate count data from high-throughput DNA sequencing
experiments, which often contain many zero values. These zeros can cause artifacts for …

Differential abundance analysis is controversial throughout microbiome research. Gold
standard approaches require laborious measurements of total microbial load, or absolute …

Background Short-chain fatty acids (SCFAs) derived from gut bacteria are associated with
protective roles in diseases ranging from obesity to colorectal cancers. Intake of microbially …

Background One of the main challenges of microbiome analysis is its compositional nature
that if ignored can lead to spurious results. Addressing the compositional structure of …

Microbe–microbe interactions in the human gut are influenced by host-derived glycans and
diet. The high complexity of the gut microbiome poses a major challenge for unraveling the …

The translational power of human microbiome studies is limited by high interindividual
variation. We describe a dimensionality reduction tool, compositional tensor factorization …

Pediatric obesity remains a public health burden and continues to increase in prevalence.
The gut microbiota plays a causal role in obesity and is a promising therapeutic target …

Microbial interactions function as a fundamental unit in complex ecosystems. By
characterizing the type of interaction (positive, negative, neutral) occurring in these dynamic …

Background It has been widely recognized that a critical time window for neurodevelopment
occurs in early life and the host's gut microbiome plays an important role in …