Traumatic brain injury (TBI) may have many different causes, including a blow to the head,
penetration of the skull, fast acceleration or deceleration of the head, or exposure to a blast …

The brain's unique characteristics make it exceptionally susceptible to oxidative stress,
which arises from an imbalance between reactive oxygen species (ROS) production …

TBI has been one of the top causes of death and morbidity worldwide, yet despite enormous
efforts to discover neuroprotective therapeutics for this serious disease, no beneficial …

Vascular smooth muscle cells (VSMCs) are the key moderators of cerebrovascular dynamics
in response to the brain's oxygen and nutrient demands. Crucially, VSMCs may provide a …

Background Exercise is a major nonpharmacological treatment for hypertension, but its
underlying mechanisms are still not completely elucidated. Irisin, a polypeptide containing …

Traumatic brain injury (TBI) is a major health problem worldwide. In addition to its high
mortality (35–40%), survivors are left with cognitive, behavioral, and communicative …

Mild traumatic brain injury (mTBI) induced by low-intensity blast (LIB) is a serious health
problem affecting military service members and veterans. Our previous reports using a …

Endothelial dysfunction is a hallmark of many chronic diseases, including diabetes and long-
term hypertension. We show that acute traumatic brain injury (TBI) leads to endothelial …

Background Recent studies demonstrate that spatially restricted, local Ca2+ signals are key
regulators of endothelium‐dependent vasodilation in systemic circulation. There are drastic …

Highlights•TBI is the main cause of death and disability in children and young
adults.•Secondary brain injury may occur for month and years after injury.•Cognitive decline …