Structural and functional consequences of reversible lipid asymmetry in living membranes
Maintenance of lipid asymmetry across the two leaflets of the plasma membrane (PM)
bilayer is a ubiquitous feature of eukaryotic cells. Loss of this asymmetry has been widely …
bilayer is a ubiquitous feature of eukaryotic cells. Loss of this asymmetry has been widely …
Molecular substructure of the liquid-ordered phase formed by sphingomyelin and cholesterol: Sphingomyelin clusters forming nano-subdomains are a characteristic …
As a model of lipid rafts, the liquid-ordered (Lo) phase formed by sphingomyelin (SM) and
cholesterol (Cho) in bilayer membranes has long attracted the attention of biophysics …
cholesterol (Cho) in bilayer membranes has long attracted the attention of biophysics …
LiPyphilic: A Python toolkit for the analysis of lipid membrane simulations
Molecular dynamics simulations are now widely used to study emergent phenomena in lipid
membranes with complex compositions. Here, we present LiPyphilic—a fast, fully tested …
membranes with complex compositions. Here, we present LiPyphilic—a fast, fully tested …
Thermal-controlled cellular uptake of “hot” nanoparticles
Nanoparticles (NPs) have shown immense potential in the field of biomedical applications,
particularly in NP-based photothermal therapy, which offers a remote-controlled approach to …
particularly in NP-based photothermal therapy, which offers a remote-controlled approach to …
Ceramide-1-phosphate transfer protein enhances lipid transport by disrupting hydrophobic lipid–membrane contacts
JR Rogers, PL Geissler - PLOS Computational Biology, 2023 - journals.plos.org
Cellular distributions of the sphingolipid ceramide-1-phosphate (C1P) impact essential
biological processes. C1P levels are spatiotemporally regulated by ceramide-1-phosphate …
biological processes. C1P levels are spatiotemporally regulated by ceramide-1-phosphate …
Complex nanoemulsion for vitamin delivery: droplet organization and interaction with skin membranes
Lipid nanoemulsions are promising nanomaterials for drug delivery applications in food,
pharmaceutical and cosmetic industries. Despite the noteworthy commercial interest, little is …
pharmaceutical and cosmetic industries. Despite the noteworthy commercial interest, little is …
[HTML][HTML] Extension of the iSoLF implicit-solvent coarse-grained model for multicomponent lipid bilayers
iSoLF is a coarse-grained (CG) model for lipid molecules with the implicit-solvent
approximation used in molecular dynamics (MD) simulations of biological membranes …
approximation used in molecular dynamics (MD) simulations of biological membranes …
Phosphatidylinositol 4, 5-bisphosphate sensing lipid raft via inter-leaflet coupling regulated by acyl chain length of sphingomyelin
Phosphatidylinositol 4, 5-bisphosphate (PIP2) is an important molecule located at the inner
leaflet of cell membrane, where it serves as anchoring sites for a cohort of membrane …
leaflet of cell membrane, where it serves as anchoring sites for a cohort of membrane …
[HTML][HTML] Polymyxin B1 in the Escherichia coli inner membrane: A complex story of protein and lipopolysaccharide-mediated insertion
The rise in multi-drug resistant Gram-negative bacterial infections has led to an increased
need for “last-resort” antibiotics such as polymyxins. However, the emergence of polymyxin …
need for “last-resort” antibiotics such as polymyxins. However, the emergence of polymyxin …
Investigation of the domain line tension in asymmetric vesicles prepared via hemifusion
The plasma membrane (PM) is asymmetric in lipid composition. The distinct and
characteristic lipid compositions of the exoplasmic and cytoplasmic leaflets lead to different …
characteristic lipid compositions of the exoplasmic and cytoplasmic leaflets lead to different …