Global quantification of protein abundances in single cells could provide direct information
on cellular phenotypes and complement transcriptomics measurements. However, single …

Sample preparation for single-cell proteomics is generally performed in a one-pot workflow
with multiple dispensing and incubation steps. These hours-long processes can be labor …

Molecular heterogeneity exists at different spatial scales in biological samples and is an
important parameter in the development of pathologies and resistances to therapies. When …

Cancer cells can evade immune responses by exploiting inhibitory immune checkpoints.
Immune checkpoint inhibitor (ICI) therapies based on anti-CTLA-4 and anti-PD-1/PD-L1 …

Dissecting the proteome of cell types and states at single-cell resolution, while being highly
challenging, has significant implications in basic science and biomedicine. Mass …

Mass spectrometry (MS) has been one of the most widely used tools for bioanalytical
analysis due to its high sensitivity, capability of quantitative analysis, and compatibility with …

Mass spectrometry (MS)-based single-cell proteomics, while highly challenging, offers
unique potential for a wide range of applications to interrogate cellular heterogeneity …

Mass spectrometry-based single-cell proteomics has undergone rapid progress and has
become an active research area. However, because of the ultralow amount of proteins in …