The astrocyte, a major glial cell type in the central nervous system (CNS), is widely regarded
as a functionally diverse mediator of homeostasis. During development and throughout …

Retinal ganglion cell (RGC) death in glaucoma and other optic neuropathies results in
irreversible vision loss due to the mammalian central nervous system's limited regenerative …

Traditional approaches to studying astrocyte heterogeneity have mostly focused on
analyzing static properties, failing to identify whether subtypes represent intermediate or …

Estrogens are pivotal regulators of brain function throughout the lifespan, exerting profound
effects from early embryonic development to aging. Extensive experimental evidence …

Abstract Background The combination of Astragalus membranaceus and Carthamus
tinctorius (AC) exhibits significant therapeutic effects in cerebral ischemia/reperfusion injury …

Microglial cells exhibit properties akin to macrophages, thereby enabling them to support
and protect the central nervous system environment. Aging induces alterations in microglial …

Parkinson's disease (PD) is a prevalent neurodegenerative disorder that affects the central
nervous system (CNS). Neuroinflammation is a crucial factor in the pathological …

Microglia are resident macrophages in the central nervous system (CNS) that play various
roles during brain development and in the pathogenesis of CNS diseases. Recently …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by
a mutant huntingtin protein with an abnormal CAG/polyQ expansion in the N-terminus of …

Astrocytes are a highly abundant glial cell type that perform critical homeostatic functions in
the central nervous system. Like neurons, astrocytes have many discrete heterogenous …