Importance: Schizophrenia is a complex syndrome with taxing symptoms and for which
treatment challenges remain. Current dopamine D 2 receptor–blocking antipsychotics have …

Psychotic symptoms are a cross-sectional dimension affecting multiple diagnostic
categories, despite schizophrenia represents the prototype of psychoses. Initially, dopamine …

Background Major depressive disorder (MDD) is a highly heterogeneous disorder that
typically emerges in adolescence and can occur throughout adulthood. Studies aimed at …

Human cognition and behaviors depend upon the brain's functional connectomes, which
vary remarkably across individuals. However, whether and how the functional connectome …

Background The high heterogeneity of obsessive–compulsive disorder (OCD) denies
attempts of traditional case–control studies to derive neuroimaging biomarkers indicative of …

BackgroundElucidating individual aberrance is a critical first step toward precision medicine
for heterogeneous disorders such as depression. The neuropathology of depression is …

BackgroundMental disorders, including depression, obsessive compulsive disorder (OCD),
and schizophrenia, share a common neuropathy of disturbed large-scale coordinated brain …

Intersubject variability is a fundamental characteristic of brain organizations, and not just
“noise”. Although intrinsic functional connectivity (FC) is unique to each individual and varies …

Background Neurobiological heterogeneity in depression remains largely unknown, leading
to inconsistent neuroimaging findings. Methods Here, we adopted a novel proposed …

Patients with obsessive compulsive disorder (OCD) exhibit tremendous heterogeneity in
structural and functional neuroimaging aberrance. However, most previous studies just …