Neuropsychiatric lupus: new mechanistic insights and future treatment directions

N Schwartz, AD Stock, C Putterman - Nature Reviews Rheumatology, 2019 - nature.com
Patients with systemic lupus erythematosus (SLE) frequently show symptoms of central
nervous system (CNS) involvement, termed neuropsychiatric SLE (NPSLE). The CNS …

Neuropsychiatric systemic lupus erythematosus: pathogenesis and biomarkers

H Jeltsch-David, S Muller - Nature Reviews Neurology, 2014 - nature.com
Systemic lupus erythematosus (SLE) is a complex clinical syndrome, elements of which
remain poorly understood. Although recognized over 140 years ago when Kaposi recorded …

Diagnosis and management of neuropsychiatric SLE

JG Hanly - Nature Reviews Rheumatology, 2014 - nature.com
Nervous system involvement in systemic lupus erythematosus (SLE) can manifest as a
range of neurological and psychiatric features, which are classified using the ACR case …

Management of neuropsychiatric systemic lupus erythematosus: current approaches and future perspectives

C Magro-Checa, EJ Zirkzee, TW Huizinga… - Drugs, 2016 - Springer
Neuropsychiatric systemic lupus erythematosus (NPSLE) is a generic definition referring to a
series of neurological and psychiatric symptoms directly related to systemic lupus …

European League Against Rheumatism recommendations for monitoring patients with systemic lupus erythematosus in clinical practice and in observational studies

M Mosca, C Tani, M Aringer, S Bombardieri… - Annals of the …, 2010 - ard.bmj.com
Objectives To develop recommendations for monitoring patients with systemic lupus
erythematosus (SLE) in clinical practice and observational studies and to develop a …

Microglia-dependent synapse loss in type I interferon-mediated lupus

AR Bialas, J Presumey, A Das, CE van der Poel… - Nature, 2017 - nature.com
Systemic lupus erythematosus (SLE) is an incurable autoimmune disease characterized by
autoantibody deposition in tissues such as kidney, skin and lungs. Notably, up to 75% of …

The management of neuropsychiatric lupus in the 21st century: still so many unmet needs?

M Govoni, JG Hanly - Rheumatology, 2020 - academic.oup.com
Neuropsychiatric (NP) events occur in the majority of patients with SLE and predominantly
affect the CNS in addition to the peripheral and autonomic systems. Approximately 30% of …

Nervous system disease in systemic lupus erythematosus: current status and future directions

JG Hanly, E Kozora, SD Beyea… - Arthritis & …, 2019 - Wiley Online Library
The American College of Rheumatology's case definitions for 19 neuropsychiatric
syndromes in systemic lupus erythematosus (SLE) constitute a comprehensive classification …

The diagnosis and clinical management of the neuropsychiatric manifestations of lupus

M Govoni, A Bortoluzzi, M Padovan, E Silvagni… - Journal of …, 2016 - Elsevier
Neuropsychiatric (NP) involvement in Systemic Lupus Erythematosus (SLE), can be a
severe and troubling manifestation of the disease that heavily impacts patient's health …

Prospective analysis of neuropsychiatric events in an international disease inception cohort of patients with systemic lupus erythematosus

JG Hanly, MB Urowitz, L Su, SC Bae… - Annals of the …, 2010 - ard.bmj.com
Objectives To determine the frequency, accrual, attribution and outcome of neuropsychiatric
(NP) events and impact on quality of life over 3 years in a large inception cohort of patients …