From an evolutionary perspective keratan sulfate (KS) is the newest glycosaminoglycan
(GAG) but the least understood. KS is a sophisticated molecule with a diverse structure, and …

Glomerular podocytes are highly specialized cells with a complex cytoarchitecture. Their
most prominent features are interdigitated foot processes with filtration slits in between …

Transformation of pluripotent epiblast cells into a cup-shaped epithelium as the mouse
blastocyst implants is a poorly understood and yet key developmental step. Studies of …

As an integral member of the filtration barrier in the kidney glomerulus, the podocyte is in a
unique geographical position: It is exposed to chemical signals from the urinary space …

The visceral glomerular epithelial cell, also called podocyte, is a terminally differentiated cell
that lines the outer aspect of the glomerular basement membrane (GBM). It therefore forms …

Podocytes of the renal glomerulus are unique cells with a complex cellular organization
consisting of a cell body, major processes and foot processes. Podocyte foot processes form …

For almost 30 years, the cell-surface protein CD34 has been widely used as a marker to
assist in the identification and isolation of hematopoietic stem cells (HSCs) and progenitors …

Proteinuria is a major health-care problem that affects several hundred million people
worldwide. Proteinuria is a cardinal sign and a prognostic marker of kidney disease, and …

Podocalyxin, a sialomucin most closely related to CD34 and endoglycan, is expressed by
kidney podocytes, hematopoietic progenitors, vascular endothelia, and a subset of neurons; …

Podocyte loss plays a key role in the progression of glomerular disorders towards
glomerulosclerosis and chronic kidney disease. Podocytes form unique cytoplasmic …