Lipids entering the gastrointestinal tract include dietary lipids (triacylglycerols, cholesteryl
esters and phospholipids) and endogenous lipids from bile (phospholipids and cholesterol) …

All living organisms can make lipid droplets (LDs), intracellular oil-in-water droplets,
surrounded by a phospholipid and protein monolayer. LDs are at the nexus of cellular lipid …

The gut microbiota play important roles in lipid metabolism and absorption. However, the
contribution of the small bowel microbiota of mammals to these diet-microbe interactions …

The mouse small intestine shows profound variability in gene expression along the crypt–
villus axis,. Whether similar spatial heterogeneity exists in the adult human gut remains …

Digested dietary fats are taken up by enterocytes where they are assembled into pre-
chylomicrons in the endoplasmic reticulum followed by transport to the Golgi for maturation …

The prevalence and diagnosis of nonalcoholic fatty liver disease (NAFLD) is on the rise
worldwide and currently has no FDA-approved pharmacotherapy. The increase in disease …

Rationale: Increased lipid droplet (LD) formation has been linked to tumor metastasis,
stemness, and chemoresistance in various types of cancer. Here, we revealed that LD …

Objective Emerging evidence suggest the existence of constant basal lipolysis and re-
esterification of a substantial fraction of thus liberated fatty acids. In stimulated lipolysis, the …

Simple Summary One of the causes of failure of anticancer therapies is the reprogramming
of lipid metabolism. Cells of innate and adaptive immunity present in the tumor …

Objective: Nobiletin is a dietary flavonoid that improves insulin resistance and
atherosclerosis in mice with metabolic dysfunction. Dysregulation of intestinal lipoprotein …