Atopic dermatitis (AD) is the most common inflammatory skin disease worldwide, affecting
20% of children and 5% of adults. One critical component in the pathophysiology of AD is …

Dysregulated signaling from TNF and TNFR proteins is implicated in several immune-
mediated inflammatory diseases (IMIDs). This review centers around seven IMIDs …

Importance The epidemiological link between immune-mediated diseases (IMIDs) and
cardiovascular disease has often been attributed to systemic inflammation. However, the …

The purpose of this study was to identify the heterogeneity of atopic dermatitis and to identify
key genetic factors. This can lead to new approaches and personalized treatment strategies …

Studies of asthma and allergy are generating increasing volumes of omics data for analysis
and interpretation. The National Institute of Allergy and Infectious Diseases (NIAID) …

Psoriasis and atopic dermatitis fall within the category of cutaneous immune-mediated
inflammatory diseases (IMIDs). The prevalence of IMIDs is increasing in industrialized …

Atopic dermatitis (AD) is a common chronic inflammatory skin disorder characterized by
disrupted epidermal barrier function and aberrant immune responses. Despite recent …

Abstract Loss-of-function (LoF) variants in the filaggrin (FLG) gene are the strongest known
genetic risk factor for atopic dermatitis (AD), but the impact of these variants on AD outcomes …

Observational studies suggest dyslipidemia as an atopic dermatitis (AD) risk factor and posit
that lipid-lowering drugs may influence AD risk, but the causal link remains elusive …

Atopic dermatitis (AD) is an immune-related skin disease with a genetic background.
Numerous loci have been identified associated with AD to better comprehend its …