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Angiotensin-converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system: celebrating the 20th anniversary of the discovery of ACE2
ACE2 (angiotensin-converting enzyme 2) has a multiplicity of physiological roles that
revolve around its trivalent function: a negative regulator of the renin-angiotensin system …
revolve around its trivalent function: a negative regulator of the renin-angiotensin system …
The ACE2/angiotensin-(1–7)/MAS axis of the renin-angiotensin system: focus on angiotensin-(1–7)
The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …
system and hydroelectrolyte balance, with an influence on organs and functions throughout …
Angiotensin-converting enzymes (ACE, ACE2) gene variants and COVID-19 outcome
The Angiotensin system is implicated in the pathogenesis of COVID-19. First, ACE2 is the
cellular receptor for SARS-CoV-2, and expression of the ACE2 gene could regulate the …
cellular receptor for SARS-CoV-2, and expression of the ACE2 gene could regulate the …
Role of the ACE2/angiotensin 1–7 axis of the renin–angiotensin system in heart failure
Heart failure (HF) remains the most common cause of death and disability, and a major
economic burden, in industrialized nations. Physiological, pharmacological, and clinical …
economic burden, in industrialized nations. Physiological, pharmacological, and clinical …
The renin-angiotensin system: going beyond the classical paradigms
Thirty years ago, a novel axis of the renin-angiotensin system (RAS) was unveiled by the
discovery of angiotensin-(1− 7)[ANG-(1− 7)] generation in vivo. Later, angiotensin …
discovery of angiotensin-(1− 7)[ANG-(1− 7)] generation in vivo. Later, angiotensin …
Protective role of ACE2 and its downregulation in SARS-CoV-2 infection leading to Macrophage Activation Syndrome: Therapeutic implications
In light of the outbreak of the 2019 novel coronavirus disease (COVID-19), the international
scientific community has joined forces to develop effective treatment strategies. The …
scientific community has joined forces to develop effective treatment strategies. The …
Angiotensin-converting enzyme 2 and angiotensin 1–7: novel therapeutic targets
F Jiang, J Yang, Y Zhang, M Dong, S Wang… - Nature Reviews …, 2014 - nature.com
The renin–angiotensin system (RAS) has pivotal roles in the regulation of normal physiology
and the pathogenesis of cardiovascular disease. Angiotensin-converting enzyme (ACE) 2 …
and the pathogenesis of cardiovascular disease. Angiotensin-converting enzyme (ACE) 2 …
Molecular biology of atherosclerosis
PN Hopkins - Physiological reviews, 2013 - journals.physiology.org
At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …
ACE2 deficiency worsens epicardial adipose tissue inflammation and cardiac dysfunction in response to diet-induced obesity
Obesity is increasing in prevalence and is strongly associated with metabolic and
cardiovascular disorders. The renin-angiotensin system (RAS) has emerged as a key …
cardiovascular disorders. The renin-angiotensin system (RAS) has emerged as a key …
ACE inhibition, ACE2 and angiotensin-(1⿿ 7) axis in kidney and cardiac inflammation and fibrosis
Abstract The Renin Angiotensin System (RAS) is a pivotal physiological regulator of heart
and kidney homeostasis, but also plays an important role in the pathophysiology of heart …
and kidney homeostasis, but also plays an important role in the pathophysiology of heart …