Apicomplexa are obligatory intracellular parasites that sense and actively invade host cells.
Invasion is a conserved process that relies on the timely and spatially controlled exocytosis …

Cbl proteins are ubiquitin ligases and multifunctional adaptor proteins that are implicated in
the regulation of signal transduction in various cell types and in response to different stimuli …

Written by more than 400 subject experts representing diverse academic and applied
domains, this multidisciplinary resource surveys the vanguard of biomaterials and …

ALIX/AIP1 functions in enveloped virus budding, endosomal protein sorting, and many other
cellular processes. Retroviruses, including HIV-1, SIV, and EIAV, bind and recruit ALIX …

The ESCRT pathway facilitates membrane fission events during enveloped virus budding,
multivesicular body formation, and cytokinesis. To promote HIV budding and cytokinesis, the …

We have investigated the function of endogenous galectin-3 in T cells. Galectin-3-deficient
(gal3−/−) CD4+ T cells secreted more IFN-γ and IL-4 than gal3+/+ CD4+ T cells after T-cell …

Directional cell migration is essential for development, chemotaxis, and wound healing and
requires cell polarization in combination with a motility stimulus. Key to the cells' capacity to …

SPARC, a 32-kDa matricellular glycoprotein, mediates interactions between cells and their
extracellular matrix, and targeted deletion of Sparc results in compromised extracellular …

Alix is a cytosolic protein in mammalian cells that was originally identified on the basis of its
association with pro-apoptotic signaling. More recent evidence has established that Alix has …

Cytokinesis is the final step in cell division. The process begins during chromosome
segregation, when the ingressing cleavage furrow begins to partition the cytoplasm between …