Cellular function is controlled through intricate networks of signals, which lead to the myriad
pathways governing cell fate. Fluorescent biosensors have enabled the study of these …

Glucose has long been considered the primary fuel source for the brain. However, glucose
levels fluctuate in the brain during sleep or circuit activity, posing major metabolic stress …

Mental illnesses arise from dysfunction in the brain. Although numerous extraneural factors
influence these illnesses, ultimately, it is the science of the brain that will lead to novel …

As the primary source of norepinephrine (NE) in the brain, the locus coeruleus (LC)
regulates both arousal and stress responses1, 2. However, how local neuromodulatory …

Deciphering the complex interplay between neuronal activity and mitochondrial function is
pivotal in understanding brain aging, a multifaceted process marked by declines in synaptic …

Background Alzheimer's disease (AD) is the most common form of dementia. Although drugs
focusing on reducing amyloid β slow progression, they fail to improve cognitive function …

Understanding the detailed mechanism of action of glucagon-like peptide 1 receptor (GLP-
1R) agonists on distinct topographic and genetically-defined brain circuits is critical for …

Postoperative cognitive dysfunction (POCD) is common in the aged population and
associated with poor clinical outcomes. Irisin, an endogenous molecule that mediates the …

Brain plasticity is at the basis of many cognitive functions, including learning and memory. It
includes several mechanisms of synaptic and extrasynaptic changes, neurogenesis, and the …

Inhibitory neurons shape the brain's computational landscape and rely on different cellular
architectures and intrinsic properties than excitatory neurons. Maintenance of the overall …