Next generation gold drugs and probes: chemistry and biomedical applications

RT Mertens, S Gukathasan, AS Arojojoye… - Chemical …, 2023 - ACS Publications
The gold drugs, gold sodium thiomalate (Myocrisin), aurothioglucose (Solganal), and the
orally administered auranofin (Ridaura), are utilized in modern medicine for the treatment of …

Gold complexes in anticancer therapy: From new design principles to particle‐based delivery systems

G Moreno‐Alcántar, P Picchetti… - Angewandte Chemie …, 2023 - Wiley Online Library
The discovery of the medicinal properties of gold complexes has fuelled the design and
synthesis of new anticancer metallodrugs, which have received special attention due to their …

Riding the metal wave: A review of the latest developments in metal-based anticancer agents

S Abdolmaleki, A Aliabadi, S Khaksar - Coordination Chemistry Reviews, 2024 - Elsevier
Metal-based complexes have demonstrated significant anticancer effects and have emerged
as candidates with great potential for cancer therapy. These agents are effective in a variety …

Beyond cisplatin: New frontiers in metallodrugs for hard-to-treat triple negative breast cancer

N Muhammad, M Hanif, P Yang - Coordination Chemistry Reviews, 2024 - Elsevier
Triple-negative breast cancer (TNBC) is the most aggressive and hard-to-treat form of breast
cancer. TNBC has a higher propensity for earlier relapse and an increased risk of metastasis …

Advances in alkynyl gold complexes for use as potential anticancer agents

Z Yang, G Jiang, Z Xu, S Zhao, W Liu - Coordination Chemistry Reviews, 2020 - Elsevier
Gold-based anticancer agents have gained the widespread attention of medicinal inorganic
chemists due to their unique chemical properties and strong antiproliferative potency …

Metal Complexes in Target‐Specific Anticancer Therapy: Recent Trends and Challenges

G Shumi, T Desalegn, TB Demissie… - Journal of …, 2022 - Wiley Online Library
Cancer is characterized by abnormal cell differentiation in or on the part of the body. The
most commonly used chemotherapeutic drugs are developed to target rapidly dividing cells …

Exploring the potential of metallodrugs as chemotherapeutics for triple negative breast cancer

N Nayeem, M Contel - Chemistry–A European Journal, 2021 - Wiley Online Library
This review focuses on studies of coordination and organometallic compounds as potential
chemotherapeutics against triple negative breast cancer (TNBC) which has one of the …

A Multitarget Gold (I) Complex Induces Cytotoxicity Related to Aneuploidy in HCT‐116 Colorectal Carcinoma Cells

JJ Zhang, MA Abu el Maaty… - Angewandte Chemie …, 2020 - Wiley Online Library
A novel alkynyl phosphane gold (I) complex (trimethylphosphane)(3‐(1, 3‐dimethylxanthine‐
7‐yl) prop‐1‐yn‐1‐yl) gold (I) 1 displayed mutiple biological activites including selective …

New achievements for the treatment of triple-negative breast cancer

A Catalano, D Iacopetta, J Ceramella, A Mariconda… - Applied Sciences, 2022 - mdpi.com
Triple-negative breast cancer (TNBC) constitutes a heterogeneous group of malignancies
that are often aggressive and associated with a poor prognosis. The development of new …

Gold (III)-P-chirogenic complex induces mitochondrial dysfunction in triple-negative breast cancer

C Olelewe, JH Kim, S Ofori, RT Mertens, S Gukathasan… - Iscience, 2022 - cell.com
Chemical agents that specifically exploit metabolic vulnerabilities of cancer cells will be
beneficial but are rare. The role of oxidative phosphorylation (OXPHOS) in promoting and …