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Harnessing the potential of induced pluripotent stem cells for regenerative medicine
The discovery of methods to convert somatic cells into induced pluripotent stem cells
(iPSCs) through expression of a small combination of transcription factors has raised the …
(iPSCs) through expression of a small combination of transcription factors has raised the …
Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells
Pluripotent stem cells, both embryonic stem cells and induced pluripotent stem cells, are
undifferentiated cells that can self-renew and potentially differentiate into all hematopoietic …
undifferentiated cells that can self-renew and potentially differentiate into all hematopoietic …
[HTML][HTML] Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon
Most organs have tissue-resident immune cells. Human organoids lack these immune cells,
which limits their utility in modeling many normal and disease processes. Here, we describe …
which limits their utility in modeling many normal and disease processes. Here, we describe …
Generation of transgene-free hematopoietic stem cells from human induced pluripotent stem cells
O Piau, M Brunet-Manquat, B L'Homme, L Petit… - Cell Stem Cell, 2023 - cell.com
Hematopoietic stem cells (HSCs) are the rare cells responsible for the lifelong curative
effects of hematopoietic cell (HC) transplantation. The demand for clinical-grade HSCs has …
effects of hematopoietic cell (HC) transplantation. The demand for clinical-grade HSCs has …
Hemangioblastic derivatives from human induced pluripotent stem cells exhibit limited expansion and early senescence
Human induced pluripotent stem cells (hiPSC) have been shown to differentiate into a
variety of replacement cell types. Detailed evaluation and comparison with their human …
variety of replacement cell types. Detailed evaluation and comparison with their human …
Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation
Enteroendocrine cells (EECs) secrete serotonin (enterochromaffin [EC] cells) or specific
peptide hormones (non-EC cells) that serve vital metabolic functions. The basis for terminal …
peptide hormones (non-EC cells) that serve vital metabolic functions. The basis for terminal …
Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinoma
Abstract Background The SRY-related HMG-box family of transcription factors member
SOX2 has been mainly studied in embryonic stem cells as well as early foregut and neural …
SOX2 has been mainly studied in embryonic stem cells as well as early foregut and neural …
Harnessing organs-on-a-chip to model tissue regeneration
Tissue engineering has markedly matured since its early beginnings in the 1980s. In
addition to the original goal to regenerate damaged organs, the field has started to explore …
addition to the original goal to regenerate damaged organs, the field has started to explore …
Targeting Wnt pathways in disease
Wnt-mediated signal transduction pathways have long been recognized for their roles in
regulating embryonic development, and have more recently been linked to cancer …
regulating embryonic development, and have more recently been linked to cancer …
Microparticle, nanoparticle, and stem cell-based oxygen carriers as advanced blood substitutes
Z Tao, PP Ghoroghchian - Trends in biotechnology, 2014 - cell.com
Here, we discuss recent advances in the development of artificial red blood cell (RBC)
substitutes, illustrating lessons learned from initial attempts using perfluorocarbon (PFC) …
substitutes, illustrating lessons learned from initial attempts using perfluorocarbon (PFC) …