Strategies to improve the EPR effect: A mechanistic perspective and clinical translation

M Ikeda-Imafuku, LLW Wang, D Rodrigues… - Journal of Controlled …, 2022 - Elsevier
Many efforts have been made to achieve targeted delivery of anticancer drugs to enhance
their efficacy and to reduce their adverse effects. These efforts include the development of …

Application of nanomaterials in biomedical imaging and cancer therapy

S Siddique, JCL Chow - Nanomaterials, 2020 - mdpi.com
Nanomaterials, such as nanoparticles, nanorods, nanosphere, nanoshells, and nanostars,
are very commonly used in biomedical imaging and cancer therapy. They make excellent …

[HTML][HTML] Alliance with EPR effect: combined strategies to improve the EPR effect in the tumor microenvironment

J Park, Y Choi, H Chang, W Um, JH Ryu, IC Kwon - Theranostics, 2019 - ncbi.nlm.nih.gov
The use of nanomedicine for cancer treatment takes advantage of its preferential
accumulation in tumors owing to the enhanced permeability and retention (EPR) effect. The …

[HTML][HTML] Recent advances in multifunctional nanomaterials for photothermal-enhanced Fenton-based chemodynamic tumor therapy

P Manivasagan, A Joe, HW Han, T Thambi… - Materials Today Bio, 2022 - Elsevier
Abstract Photothermal (PT)-enhanced Fenton-based chemodynamic therapy (CDT) has
attracted a significant amount of research attention over the last five years as a highly …

Emerging strategies of nanomaterial‐mediated tumor radiosensitization

J **e, L Gong, S Zhu, Y Yong, Z Gu… - Advanced …, 2019 - Wiley Online Library
Nano‐radiosensitization has been a hot concept for the past ten years, and the nanomaterial‐
mediated tumor radiosensitization method is mainly focused on increasing intracellular …

Nanomaterial-based contrast agents

JC Hsu, Z Tang, OE Eremina, AM Sofias… - Nature Reviews …, 2023 - nature.com
Medical imaging, which empowers the detection of physiological and pathological
processes within living subjects, has a vital role in both preclinical and clinical diagnostics …

Magnetic functionalized nanoparticles for biomedical, drug delivery and imaging applications

SD Anderson, VV Gwenin, CD Gwenin - Nanoscale research letters, 2019 - Springer
Medicine is constantly looking for new and improved treatments for diseases, which need to
have a high efficacy and be cost-effective, creating a large demand on scientific research to …

Aggregation‐induced emission gold clustoluminogens for enhanced low‐dose X‐ray‐induced photodynamic therapy

W Sun, L Luo, Y Feng, Y Cai, Y Zhuang… - Angewandte …, 2020 - Wiley Online Library
The use of gold nanoparticles as radiosensitizers is an effective way to boost the killing
efficacy of radiotherapy while drastically limiting the received dose and reducing the …

Update on multienergy CT: physics, principles, and applications

P Rajiah, A Parakh, F Kay, D Baruah… - Radiographics, 2020 - pubs.rsna.org
Multienergy CT involves acquisition of two or more CT measurements with distinct energy
spectra. Using the differential attenuation of tissues and materials at different x-ray energies …

The mechanisms of nanoparticle delivery to solid tumours

LNM Nguyen, W Ngo, ZP Lin, S Sindhwani… - Nature Reviews …, 2024 - nature.com
Nanoparticles for the detection and treatment of cancer have suffered from limited clinical
translation. A key problem has been the lack of understanding of the mechanisms of …