Thiazole: A versatile standalone moiety contributing to the development of various drugs and biologically active agents
For many decades, the thiazole moiety has been an important heterocycle in the world of
chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) …
chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) …
Development of novel pyridine-thiazole hybrid molecules as potential anticancer agents
Novel pyridine-thiazole hybrid molecules were synthesized and subjected to physico-
chemical characterization and screening of their cytotoxic action towards a panel of cell lines …
chemical characterization and screening of their cytotoxic action towards a panel of cell lines …
Blockage of the monoamine oxidase by a natural compound to overcome parkinson's disease via computational biology
M Sherafatizangeneh, C Farshadfar… - Journal of …, 2022 - World Scientific
The dopamine (DA) metabolism changes are significant in Parkinson's disease (PD). Levels
of monoamine oxidases (MAOs) play a critical role in DA metabolism and oxidative damage …
of monoamine oxidases (MAOs) play a critical role in DA metabolism and oxidative damage …
In-silico evaluations of the isolated phytosterols from polygonum hydropiper L against BACE1 and MAO drug targets
Our previous anti-Alzheimer's studies on crude extracts, essential oils and isolated
compounds including β-sitostrol from Polygonum hydropiper L, motivated us for further …
compounds including β-sitostrol from Polygonum hydropiper L, motivated us for further …
[HTML][HTML] Development of Escherichia coli asparaginase II for the treatment of acute lymphocytic leukemia: In silico reduction of asparaginase II side effects by a novel …
Acute lymphoblastic leukemia (ALL) is a common blood disease in children that is
accountable for many deaths. Due to major improvements in treatment procedures in the …
accountable for many deaths. Due to major improvements in treatment procedures in the …
[HTML][HTML] The SARS-Cov-2 Proliferation blocked by a novel and potent main protease inhibitor via computer-aided drug design
The recent prevalence of novel “coronavirus disease 2019” has expanded quickly globally,
causing a universal pandemic. Herein, an effort was constructed to design a potent drug to …
causing a universal pandemic. Herein, an effort was constructed to design a potent drug to …
Prevention of SARS-CoV-2 proliferation with a novel and potent main protease inhibitor by docking, ADMET, MM-PBSA, and molecular dynamics simulation
A Noorbakhsh, RH Askandar, MS Alhagh… - Journal of …, 2021 - World Scientific
COVID-19 is the last disease caused by SARS-CoV-2 associated with a severe immune
response and lung damage. The main protease (Mpro) has a vital role in SARS-CoV-2 …
response and lung damage. The main protease (Mpro) has a vital role in SARS-CoV-2 …
UM-164, a dual inhibitor of c-Src and p38 MAPK, suppresses proliferation of glioma by reducing YAP activity
H Xu, Y Zhang, J Liu, J Cui, Y Gan, Z Wu, Y Chang… - Cancers, 2022 - mdpi.com
Simple Summary UM-164, as a high-potency c-Src inhibitor, is the original lead compound
to be developed for targeting triple-negative breast cancer. Here we validated the fact that …
to be developed for targeting triple-negative breast cancer. Here we validated the fact that …
Early Blockage of Mycobacterium Tuberculosis Cell-wall Synthesis via EchA\6 Inhibition to Overcome Resistance Strain: Insights from Umbrella Sampling Simulations
Background: Tuberculosis (TB) has long been the major infectious cause of mortality,
ranking higher than HIV/AIDS as the most common cause of death from a single infectious …
ranking higher than HIV/AIDS as the most common cause of death from a single infectious …
A consequence of drug targeting of aminoacyl‐tRNA synthetases in Mycobacteriumtuberculosis
U Ndagi, HM Kumalo… - Chemical Biology & Drug …, 2021 - Wiley Online Library
Drug‐resistant Mycobacterium tuberculosis poses a great threat to public health and
remains one of the red‐flag tagged infectious diseases, with the tendency of comorbidity …
remains one of the red‐flag tagged infectious diseases, with the tendency of comorbidity …