The common and persistent failures to translate promising preclinical drug candidates into
clinical success highlight the limited effectiveness of disease models currently used in drug …

Precision medicine is about matching the right drugs to the right patients. Although this
approach is technology agnostic, in cancer there is a tendency to make precision medicine …

Motivation Screening bioactive compounds in cancer cell lines receive more attention.
Multidisciplinary drugs or drug combinations have a more effective role in treatments and …

Personalized medicine aims to match the right drug with the right patient by using specific
features of the individual patient's tumor. However, current strategies of personalized …

We generated ex vivo drug-response and multiomics profiling data for a prospective series
of 252 samples from 186 patients with acute myeloid leukemia (AML). A functional precision …

Recent major advances in understanding the molecular basis of acute myeloid leukemia
(AML) provide a double-edged sword. Although defining the topology and key features of …

The essential job of precision medicine is to match the right drugs to the right patients. In
cancer, precision medicine has been nearly synonymous with genomics. However, sobering …

Computational drug repositioning or repurposing is a promising and efficient tool for
discovering new uses from existing drugs and holds the great potential for precision …

Chimeric antigen receptor (CAR) T-cell therapy has proven effective in relapsed and
refractory B-cell malignancies, but resistance and relapses still occur. Better understanding …

Medicine and healthcare are undergoing profound changes. Whole-genome sequencing
and high-resolution imaging technologies are key drivers of this rapid and crucial …