Predictive overfitting in immunological applications: Pitfalls and solutions

JP Gygi, SH Kleinstein, L Guan - Human Vaccines & …, 2023 - Taylor & Francis
Overfitting describes the phenomenon where a highly predictive model on the training data
generalizes poorly to future observations. It is a common concern when applying machine …

Semi-supervised Omics Factor Analysis (SOFA) disentangles known and latent sources of variation in multi-omic data

T Capraz, H Vöhringer, KSA Kruger Serrano… - bioRxiv, 2024 - biorxiv.org
Abstract Group Factor Analysis is a family of methods for representing patterns of correlation
between features in tabular data. Argelaguet et al. identify latent factors within and across …

Dimensionality reduction methods for high-dimensional biological data analysis

KT Capraz - 2024 - archiv.ub.uni-heidelberg.de
Disease progression and response to treatments can strongly differ between patients, due to
each individual's unique genetic, environmental and molecular factors. Precision medicine …

Supervised Integration of Multi-Omics Immune Profiles via Latent Factor Modeling

J Gygi - 2024 - search.proquest.com
Advances in high-throughput technologies such as RNA-seq, metabolomics, proteomics,
and cytometry have enabled the simultaneous collection of vast amounts of high …