The B-cell receptor signaling pathway as a therapeutic target in CLL
Targeted therapy with imatinib and other selective tyrosine kinase inhibitors has transformed
the treatment of chronic myeloid leukemia. Unlike chronic myeloid leukemia, chronic …
the treatment of chronic myeloid leukemia. Unlike chronic myeloid leukemia, chronic …
B cell receptor signaling in chronic lymphocytic leukemia
B cell receptor (BCR) signaling plays an important pathogenic role in chronic lymphocytic
leukemia (CLL) and B cell lymphomas, based on structural restrictions of the BCR, and BCR …
leukemia (CLL) and B cell lymphomas, based on structural restrictions of the BCR, and BCR …
The lymph node microenvironment promotes B-cell receptor signaling, NF-κB activation, and tumor proliferation in chronic lymphocytic leukemia
Y Herishanu, P Pérez-Galán, D Liu… - Blood, The Journal …, 2011 - ashpublications.org
Chronic lymphocytic leukemia (CLL), an incurable malignancy of mature B lymphocytes,
involves blood, bone marrow, and secondary lymphoid organs such as the lymph nodes …
involves blood, bone marrow, and secondary lymphoid organs such as the lymph nodes …
B-cell receptor signaling in chronic lymphocytic leukemia
FK Stevenson, S Krysov, AJ Davies… - Blood, The Journal …, 2011 - ashpublications.org
The B-cell receptor (BCR) is a key survival molecule for normal B cells and for most B-cell
malignancies. Recombinatorial and mutational patterns in the clonal immunoglobulin (Ig) of …
malignancies. Recombinatorial and mutational patterns in the clonal immunoglobulin (Ig) of …
Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia
The genetic lesions identified to date do not fully recapitulate the molecular pathogenesis of
chronic lymphocytic leukemia (CLL) and do not entirely explain the development of severe …
chronic lymphocytic leukemia (CLL) and do not entirely explain the development of severe …
Antineoplastic mechanisms of niclosamide in acute myelogenous leukemia stem cells: inactivation of the NF-κB pathway and generation of reactive oxygen species
Y **, Z Lu, K Ding, J Li, X Du, C Chen, X Sun, Y Wu… - Cancer research, 2010 - AACR
NF-κB may be a potential therapeutic target for acute myelogenous leukemia (AML)
because NF-κB activation is found in primitive human AML blast cells. In this report, we …
because NF-κB activation is found in primitive human AML blast cells. In this report, we …
Biological and clinical implications of BIRC3 mutations in chronic lymphocytic leukemia
F Diop, R Moia, C Favini, E Spaccarotella… - …, 2019 - pmc.ncbi.nlm.nih.gov
BIRC3 is a recurrently mutated gene in chronic lymphocytic leukemia (CLL) but the
functional implications of BIRC3 mutations are largely unexplored. Furthermore, little is …
functional implications of BIRC3 mutations are largely unexplored. Furthermore, little is …
Mechanisms of B cell receptor activation and responses to B cell receptor inhibitors in B cell malignancies
The B cell receptor (BCR) pathway has been identified as a potential therapeutic target in a
number of common B cell malignancies, including chronic lymphocytic leukemia, diffuse …
number of common B cell malignancies, including chronic lymphocytic leukemia, diffuse …
Epigenetic Upregulation of lncRNAs at 13q14.3 in Leukemia Is Linked to the In Cis Downregulation of a Gene Cluster That Targets NF-kB
A Garding, N Bhattacharya, R Claus, M Ruppel… - PLoS …, 2013 - journals.plos.org
Non-coding RNAs are much more common than previously thought. However, for the vast
majority of non-coding RNAs, the cellular function remains enigmatic. The two long non …
majority of non-coding RNAs, the cellular function remains enigmatic. The two long non …
Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells
The protein kinase Syk is a key mediator of proximal B-cell receptor (BCR) signaling.
Following antigen stimulation, Syk is recruited to the BCR and becomes activated by …
Following antigen stimulation, Syk is recruited to the BCR and becomes activated by …