DNA double-strand breaks (DSBs) are the most dangerous type of DNA damage because
they can result in the loss of large chromosomal regions. In all mammalian cells, DSBs that …

Non-homologous DNA end joining (NHEJ) is the predominant repair mechanism of any type
of DNA double-strand break (DSB) during most of the cell cycle and is essential for the …

Nonhomologous DNA end-joining (NHEJ) is the predominant double-strand break (DSB)
repair pathway throughout the cell cycle and accounts for nearly all DSB repair outside of …

Immunoglobulins emerging from B lymphocytes and capable of recognizing almost all kinds
of antigens owing to the extreme diversity of their antigen‐binding portions, known as …

DNA double-strand breaks pose a serious threat to genome stability. In vertebrates, these
breaks are predominantly repaired by nonhomologous end joining (NHEJ), which pairs DNA …

Mutations in the ATM tumor suppressor gene confer hypersensitivity to DNA-damaging
chemotherapeutic agents. To explore genetic resistance mechanisms, we performed …

DNA double-strand breaks (DSBs) are accidental lesions generated by various endogenous
or exogenous stresses. DSBs are also genetically programmed events during the V (D) J …

DNA double-strand breaks (DSBs), one of the most cytotoxic forms of DNA damage, can be
repaired by the tightly regulated nonhomologous end joining (NHEJ) machinery (Stinson …

Nonhomologous end joining is a critical mechanism that repairs DNA double-strand breaks
in human cells. In this work, we address the structural and functional role of the accessory …

One of the most central questions about the repair of a double-strand DNA break (DSB)
concerns how the two free DNA ends are brought together—a step called synapsis. Using …