The prokineticins (PKs) were discovered approximately 20 years ago as small peptides
inducing gut contractility. Today, they are established as angiogenic, anorectic, and …

The mammalian prokineticins family comprises two conserved proteins, EG-VEGF/PROK1
and Bv8/PROK2, and their two highly related G protein-coupled receptors, PKR1 and PKR2 …

The specific functions of sensory systems depend on the tissue-specific expression of genes
that code for molecular sensor proteins that are necessary for stimulus detection and …

Abstract Prokineticin-2 (PK2), a recently discovered secreted protein, regulates important
physiological functions including olfactory biogenesis and circadian rhythms in the CNS …

A widely dispersed network of hypothalamic GnRH neurons controls the reproductive axis in
mammals. Genetic investigation of the human disease model of isolated GnRH deficiency …

The Bv8/Prokineticins (PKs) are a new family of peptides identified in frog, fish, reptiles and
mammals that signal through two highly homologous G-protein coupled receptors, PKR1 …

Background—Pain triggers a homeostatic alarm reaction to injury. It remains unknown,
however, whether nociceptive signaling activated by ischemia is relevant for progenitor cells …

Prokineticin signaling comprises two secreted proteins (Prok-1 and Prok-2) and two cognate
G-protein coupled receptors (PK-R1 and PK-R2) that are widely expressed in different …

Prokineticins are secreted peptides that activate two G protein-coupled receptors: PKR1 and
PKR2. Prokineticins induce angiogenesis and fenestration, but the cognate receptors …

Objective—Identification of novel factors that contribute to myocardial repair and collateral
vessel growth hold promise for treatment of heart diseases. We have shown that transient …