Antimicrobial peptides: mechanism of action, activity and clinical potential
QY Zhang, ZB Yan, YM Meng, XY Hong, G Shao… - Military Medical …, 2021 - Springer
The management of bacterial infections is becoming a major clinical challenge due to the
rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome …
rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome …
Role of lipids in the interaction of antimicrobial peptides with membranes
Antimicrobial peptides (AMPs) take part in the immune system by mounting a first line of
defense against pathogens. Recurrent structural and functional aspects are observed …
defense against pathogens. Recurrent structural and functional aspects are observed …
Antimicrobial mechanisms and clinical application prospects of antimicrobial peptides
X Li, S Zuo, B Wang, K Zhang, Y Wang - Molecules, 2022 - mdpi.com
Antimicrobial peptides are a type of small-molecule peptide that widely exist in nature and
are components of the innate immunity of almost all living things. They play an important role …
are components of the innate immunity of almost all living things. They play an important role …
One-step synthesis of high-density peptide-conjugated gold nanoparticles with antimicrobial efficacy in a systemic infection model
The increase in antibiotic drug resistance and the low number of new antibacterial drugs
approved in the last few decades requires the development of new antimicrobial strategies …
approved in the last few decades requires the development of new antimicrobial strategies …
[HTML][HTML] SFG studies on interactions between antimicrobial peptides and supported lipid bilayers
The mode of action of antimicrobial peptides (AMPs) in disrupting cell membrane bilayers is
of fundamental importance in understanding the efficiency of different AMPs, which is crucial …
of fundamental importance in understanding the efficiency of different AMPs, which is crucial …
Antimicrobial peptides in infectious diseases and beyond—a narrative review
Despite recent medical research and clinical practice developments, the development of
antimicrobial resistance (AMR) significantly limits therapeutics for infectious diseases. Thus …
antimicrobial resistance (AMR) significantly limits therapeutics for infectious diseases. Thus …
Bactericidal activity of LFchimera is stronger and less sensitive to ionic strength than its constituent lactoferricin and lactoferrampin peptides
JGM Bolscher, R Adao, K Nazmi, PAM van den Keybus… - Biochimie, 2009 - Elsevier
The innate immunity factor lactoferrin harbours two antimicrobial moieties, lactoferricin and
lactoferrampin, situated in close proximity in the N1 domain of the molecule. Most likely they …
lactoferrampin, situated in close proximity in the N1 domain of the molecule. Most likely they …
[HTML][HTML] Synergistic effects of the membrane actions of cecropin-melittin antimicrobial hybrid peptide BP100
Abstract BP100 (KKLFKKILKYL-NH 2) is a short cecropin A-melittin hybrid peptide, obtained
through a combinatorial chemistry approach, which is highly effective in inhibiting both the in …
through a combinatorial chemistry approach, which is highly effective in inhibiting both the in …
What can light scattering spectroscopy do for membrane‐active peptide studies?
Highly charged peptides are important components of the immune system and belong to an
important family of antibiotics. Although their therapeutic activity is known, most of the …
important family of antibiotics. Although their therapeutic activity is known, most of the …
Unravelling a mechanism of action for a cecropin A-melittin hybrid antimicrobial peptide: the induced formation of multilamellar lipid stacks
An understanding of the mechanism of action of antimicrobial peptides is fundamental to the
development of new and more active antibiotics. In the present work, we use a wide range of …
development of new and more active antibiotics. In the present work, we use a wide range of …